Along with its needed effects, ethinyl estradiol / norgestimate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking ethinyl estradiol / norgestimate: Some side effects of ethinyl estradiol / norgestimate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Ortho Tri-Cyclen Lo (ethinyl estradiol-norgestimate)." Ortho Mc Neil Pharmaceutical, Raritan, NJ. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to ethinyl estradiol / norgestimate: oral tablet The most frequently reported side effects were headache/migraine, nausea/vomiting, gastrointestinal disorder, diarrhea, abdominal/gastrointestinal pain, vaginal infection, genital discharge, breast issues (including breast pain, discharge, and enlargement), dysmenorrhea, metrorrhagia, abnormal withdrawal bleeding, mood disorders (including depression and mood altered), flatulence, nervousness, rash, and changes in weight (including weight increased or decreased). Very common (10% or more): Breast issues (10.3%), dysmenorrhea, metrorrhagia, abnormal withdrawal bleeding Common (1% to 10%): Vaginal infection, genital discharge, breast tenderness, breast pain, breast enlargement, breast swelling, breast discharge, breast discomfort, nipple pain, menstrual discomfort, menstrual disorder, vulvovaginal infection, urinary tract infection, amenorrhea, premenstrual syndrome Uncommon (0.1% to 1%): Ovarian cyst, vulvovaginal dryness Rare (less than 0.1%): Vaginal discharge Frequency not reported: Suppressed lactation Very common (10% or more): Nausea/vomiting (16.3%), gastrointestinal disorder, diarrhea Common (1% to 10%): Abdominal/gastrointestinal pain, flatulence, abdominal distention, constipation Rare (less than 0.1%): Pancreatitis Uncommon (0.1% to 1%): Palpitation, thrombosis, hypertension, hot flush Rare (less than 0.1%): Tachycardia, arterial thromboembolism Frequency not reported: Myocardial infarction, venous thromboembolic event, deep vein thrombosis Common (1% to 10%): Rash, acne Uncommon (0.1% to 1%): Alopecia, hirsutism, urticaria, pruritus, erythema, skin discoloration Rare (less than 0.1%): Hyperhidrosis, photosensitivity reaction Frequency not reported: Angioedema, erythema nodosum, night sweats Uncommon (0.1% to 1%): Cervical dysplasia Rare (less than 0.1%): Breast cyst Frequency not reported: Breast cancer, carcinoma of the cervix in situ, hepatic adenoma, breast cancer, benign breast neoplasm, focal nodular hyperplasia, fibroadenoma of breast1. 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