Transdermal clonidine is used alone or in combination with other medications to treat high blood pressure. Clonidine is in a class of medications called centrally acting alpha-agonist hypotensive agents. It works by decreasing your heart rate and relaxing the blood vessels so that blood can flow more easily through the body. Transdermal clonidine comes as a patch to apply to the skin. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Do not apply it more or less often than prescribed by your doctor. Apply clonidine patches to clean, dry skin on a hairless area on the upper, outer arm or upper chest. Choose an area where it will not be rubbed by tight clothing. Do not apply patches to skin that has wrinkles or folds or to skin that is cut, scraped, irritated, scarred or recently shaved. valtrex shelf life Do not interrupt or stop taking this medicine without first checking with your doctor. 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