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    People with depression are usually managed in primary care and antidepressants are often the first-line treatment, but only one third of patients respond fully to a single antidepressant. This paper describes the protocol for a randomised controlled trial (MIR) to investigate the extent to which the addition of the antidepressant mirtazapine is effective in reducing the symptoms of depression compared with placebo in patients who are still depressed after they have been treated with a selective serotonin reuptake inhibitor (SSRI) or serotonin and noradrenaline reuptake inhibitor (SNRI) for at least 6 weeks in primary care. MIR is a two-parallel group, multi-centre, pragmatic, placebo controlled, randomised trial with allocation at the level of the individual. Eligible participants are those who: are aged 18 years or older; are currently taking an SSRI/SNRI antidepressant (for at least 6 weeks at an adequate dose); score ≥14 on the Beck Depression Inventory (BDI-II); have adhered to their medication; and meet ICD-10 criteria for depression (assessed using the Clinical Interview Schedule-Revised version). Participants who give written, informed consent, will be randomised to receive either oral mirtazapine or matched placebo, starting at 15 mg daily for 2 weeks and increasing to 30 mg daily thereafter, for up to 12 months (to be taken in addition to their usual antidepressant). Participants, their GPs, and the research team will all be blind to the allocation. The primary outcome will be depression symptoms at 12 weeks post randomisation, measured as a continuous variable using the BDI-II. Remeron - Mood Treatment Center propecia pronunciation Sertraline and mirtazapine as geriatric. - Semantic Scholar Can I take Mirtazapine and Sertraline at the same time.
     
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    I was diagnosed with GAD, OCD and ADHD about 2 months ago. I started out taking 25mg of Zoloft, then 50, 75 and now I am taking 100mg. I felt pretty good when I was taking 50 mg, but since I have been on 100mg (4 days now)I feel much more anxious and I frequently get that "lump in my throat" feeling of panic. Would the increased dosage cause me to be more anxious? Is it possible that it could diminish in time, just like some others side effects do? (like dry mouth) The doctor wants me to go to 150 mg in about 3 days and I don't know if I could do it. She is hoping that the higher dosage will make me less anxious and also help with the OCD rituals that I do. Zoloft Dosage Question - Depression/Mental Health - MedHelp levitra brand Zoloft Dosage - forum. Zoloft generic. Price of zoloft. Uses, Dosage, Side
     
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