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    The FDA recently released a Drug Safety Communication announcing revisions to metformin’s label to expand use in people with type 2 diabetes and mild to moderate kidney (renal) impairment. Previously, the FDA advised against using metformin (Glucophage, Glumetza, Riomet, and Fortamet) in this group. The news could bring metformin to as many as 1.6 million more people with diabetes – a major win for the most widely prescribed diabetes drug. Metformin – a safe, cheap, and effective first-line drug in type 2 diabetes – was approved back in 1994. At the time, the FDA had concerns that metformin (which is cleared from the body through the kidneys) would accumulate in the bloodstream of people with reduced kidney function and put them at risk for lactic acidosis – a serious life-threatening condition if left untreated. As a result, the FDA prohibited metformin use for people with moderate to mild kidney disease. Physicians could still prescribe the drug “off-label,” though the safety warning certainly prevented many from accessing the drug. Stopping metformin Side effects, risks, and how to stop safely diflucan for ringworm dosage Effect of Metformin on Different Non-Diabetes Related Conditions, a. Metformin is Safe for Over 1 Million More People with Type 2.
     
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