Hi, Dietdoc recommends Xenical/orlistat to readers who have repeatedly tried to loose weight and failed. I'm one of those - have about 25kg's to loose. However, I dislike the idea of having to go beg my doctor to prescribe Xenical for me. I guess this is because I don't like the idea of using diet pills - even if they are approved by doctors and will feel like a failure for not being able to loose weight on my own. However I am insulin resistant and on Metformin, and I'm getting desperate. I've been trying to loose the 25kg for over 4 years now - since being diagnosed with PCOS and insulin resistance - but all I ever loose is some water weight - not real fat loss. 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