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    MRI signal abnormalities in the disc have been described predominantly as low signal intensity on T2 weighted images. Loss of disc height and disc calcification are the most common spine imaging manifestations. Homogentisic acid and its metabolites are deposited in fibrous and connective tissues including the intervertebral disc leading to premature degeneration. D., Non ASSR Member Excerpta Extraordinaire Mentor Award: No Institution where work was conducted William Beaumont Hospital Affiliation and Department Diagnostic Radiology, William Beaumont Hospital 100 RO Address 3601 W. Royal Oak, Michigan 48073 Phone: 2488980648, Fax: 2488985490 Email: [email protected] Alkaptonuria (Ochronosis) is a rare metabolic disorder characterized by deficiency of homogentisic acid oxidase. Increased signal intensity on T1 weighted images in connective tissue elsewhere in the body has been described due to the paramagnetic effects of the deposited metabolites. We present a case of a 49 year old man who presented with acute radiculopathy superimposed on chronic back pain who did not have an established diagnosis of alkaptonuria. MRI demonstrated a hyperintense disc on T1 weighted images. The imaging findings and the nature of the disc led to a diagnostic evaluation that confirmed the diagnosis of alkaptonuria. Chemical Name: VALACYCLOVIR (val-ay-SYE-kloe-veer)Take VALTREX immediately after it has been prescribed by your doctor and during the first appearance of symptoms such as tingling, burning, blister for optimal results. Drink plenty of water while you are taking VALTREX to keep your kidneys working properly. Your symptoms may get better before the infection is completely treated. Take this medication for the entire length of time prescribed by your doctor. Lesions caused by herpes viruses should be kept as clean and dry as possible. Wearing loose clothing may help to prevent irritation of the lesions. Take this medication for the entire length of time prescribed by your doctor. Take VALTREX immediately after it has been prescribed by your doctor and during the first appearance of symptoms such as tingling, burning, blister for optimal results. Drink plenty of water while you are taking VALTREX to keep your kidneys working properly. Your symptoms may get better before the infection is completely treated. Lesions caused by herpes viruses should be kept as clean and dry as possible. Wearing loose clothing may help to prevent irritation of the lesions.

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