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This content has not been reviewed within the past year and may not represent Web MD's most up-to-date information. Food and Drug Administration on Friday gave its approval to the first generic version of the powerful pain reliever Celebrex (celecoxib). To find the most current information, please enter your topic of interest into our search box. Celecoxib is a member of the cox-2 inhibitor family of painkillers, prescription medicines often used for arthritis and other conditions. The drugs emerged in the early 2000s and included once best-selling pain relievers such as Vioxx and Bextra. However, Vioxx was pulled from the market in 2004 after studies revealed use of the drug raised heart risks, and the withdrawal of Bextra followed a year later. Celebrex has remained the only cox-2 inhibitor medication on drugstore shelves in the years since. 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