In Sjögren’s, Plaquenil is used to treat many symptoms of Sjögren’s including fatigue, joint symptoms of arthritis and arthralgias (joint pain), dry mouth and dry eyes. Similar to its use in systemic lupus erythematosus, many clinicians feel that it is useful in reducing general Sjögren’s “disease activity.” One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. Plaquenil coraquin Using chloroquine to treat glioblastoma Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Anyway I was diagnosed with dry macular degeneration 7 years ago. A recent exam showed it has worsened. I have also seen 3 rheumatologists, and 2 of them say I should take Plaquenil and the risk of damage to my macula is not big enough to not take the Plaquenil. Diagnosis Hydroxychloroquine-induced retinal toxicity Discussion. Chloroquine CQ and hydroxychloroquine Plaquenil HCQ have been used for many years, initially for the treatment of malaria but now more commonly for the treatment of inflammatory diseases such as rheumatoid arthritis and lupus 1. It is now considered for new disease applications in diabetes, heart disease and adjunct cancer therapies 2. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. Plaquenil treatment with macular degeneration Common Medications That May Be Toxic to the Retina, What about Plaquenil and Macular Degeneration? - Inspire Chloroquine hydrochloride If you have any questions or want more information about any drug on this list and its possible links to macular degeneration, talk to your prescribing physician and/or ophthalmologist. You may also want to discuss whether the use of a drug on this list outweighs the increased risk of side effects compared with other treatments. Medication Cautions in Macular Degeneration - AMDF. Hydroxychloroquine Plaquenil Toxicity and.. The Risk of Retinal Toxicity with Plaquenil. The major macular disease which we know more about is age-related macular degeneration ARMD for which the NIH has guideline to help protect the macula including oral supplements of lutein and zeaxanthin. It is not known whether this would benefit patients on HCQ or those with toxicity. When people recovered from Macular degeneration n/a Effectiveness of Plaquenil when people have Macular degeneration * not at all 0.0 % ; somewhat 0.0 % ; moderate 0.0 % ; high 0.0 % ; very high 100 % ; Time on Plaquenil when people have Macular degeneration * 1 month 0.0 % ; 1 - 6 months 0.0 % ; 6 - 12 months 0.0 % Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus.