Malaria resistance to chloroquine

Discussion in 'Plaquenil Generic' started by dll, 01-Mar-2020.

  1. kosmocat Well-Known Member

    Malaria resistance to chloroquine


    Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.

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    Chloroquine was first discovered in 1934 and for decades was widely used as a cheap and safe drug both to treat malaria, and as a prophylaxis. However, in the 1980s, widespread resistance developed in the parasite causing the most pathogenic form of malaria, Plasmodium falciparum. CDC has no limits on the use of chloroquine for the prevention of malaria. Chloroquine, an anti-malaria drug that President Trump fast-tracked for clinical testing this week in the fight against coronavirus, can be deadly for kids, according to an Oklahoma family who said

    Chloroquine is also used to treat amebiasis (infection caused by amoebae). Chloroquine is used to treat and to prevent malaria.

    Malaria resistance to chloroquine

    On the Mechanism of Chloroquine Resistance in Plasmodium., Medicines for the Prevention of Malaria While Traveling.

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  5. Chloroquine resistance is widespread. Chloroquine should not be used for treatment of P. falciparum infections from areas of chloroquine resistance or malaria occurring in patients where chloroquine prophylaxis has failed. Patients infected with a resistant strains of plasmodia should be treated with another antimalarial drug.

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    The development of chloroquine resistance by malaria parasites is increasing at an alarming rate especially in the tropical countries where it is used extensively as an antimalarial drug 2. In the past years, the drug of choice has changed from chloroquine to artemisinin. Chloroquine, an old malaria drug, may help treat novel coronavirus, doctors say Chloroquine, or hydroxychloroquine, has been used to treat malaria since 1944. In P. falciparum the cause of the most lethal human malaria, chloroquine resistance is linked to multiple mutations in PfCRT, a protein that likely functions as a transporter in the parasite’s digestive vacuole membrane. Rapid diagnostic assays for PfCRT mutations are already employed as surveillance tools for drug resistance.

     
  6. tatauto.ru XenForo Moderator

    Warning for non-medical redditors: Chloroquine is promising, but it's possible to OD on it and cause blindness among other things, especially if you have certain genetics. Is anyone researching that, or are any of the regions fighting the outbreak trying that proactively? Chloroquine phosphate REEF2REEF Saltwater and Reef Aquarium Forum Chloroquine phosphate Page 2 Louisiana Reef Club Claim that chloroquine can prevent coronavirus a scam.
     
  7. stokkk XenForo Moderator

    Retinal Physician - Hydroxychloroquine Maculopathy An. Parafoveal sensitivity loss is an early sign that may precede fundus changes. A computerized white-on-white 10-2 visual field test enables good resolution to test for macular sensitivity. The wider visual field tests, such as 24-2, are not sufficiently sensitive to screen the parafoveal region and may miss small scotomas.

    SD-OCT As screening test for hydroxychloroquine retinopathy.