Chloroquine lysosome

Discussion in 'Plaquenil Generic' started by Motromen, 15-Mar-2020.

  1. Moroz XenForo Moderator

    Chloroquine lysosome


    Detailed information on how Wiley uses cookies can be found in our Privacy Policy. Autophagy is an important cell recycling program responsible for the clearance of damaged or long-lived proteins and organelles.

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    The clinical usefulness of chloroquine, and in some recent cases of quinine as well, has been much reduced by the evolution and spread of chloroquine resistant malaria parasites. The mechanism of resistance involves a reduced accumulation of the drug, although again the mechanism involved is controversial. Chloroquine is also a lysosomotropic agent, meaning it accumulates preferentially in the lysosomes of cells in the body. The pK a for the quinoline nitrogen of chloroquine is 8.5, meaning it is about 10% deprotonated at physiological pH as calculated by the Henderson-Hasselbalch equation. Chloroquine is a known lysosomotropic agent that increases lysosomal pH by accumulating within lysosomes as a deprotonated weak base. To study the effects of lysosomal dysfunction in ARPE-19, it was necessary to establish an in vitro model utilizing chloroquine.

    Bafilomycin A1 and chloroquine are commonly used compounds that inhibit autophagy by targeting the lysosomes but through distinct mechanisms. Pharmacological modulators of this pathway have been extensively utilized in a wide range of basic research and pre-clinical studies.

    Chloroquine lysosome

    Chloroquine Oral Uses, Side Effects, Interactions., Chloroquine - Wikipedia

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  7. It is thus not surprising that chloroquine/hydroxychloroquine is concentrated within acidic organelles such as the endosome, Golgi vesicles, and the lysosomes, where the pH is low and most chloroquine/hydroxychloroquine molecules are positively charged.

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    Chloroquine is used to treat and to prevent malaria. Chloroquine is also used to treat amebiasis infection caused by amoebae. Chloroquine may also be used for purposes not listed in this medication guide. Chloroquine is a lysosomotropic agent as it is usually prepared as a diprotic weak base pKa 8.5. The unprotonated form of chloroquine preferentially accumulates in lysosomes as it rapidly diffuses across cell/organelle membranes. Oct 01, 2018 Chloroquine phosphate tablets, Chloroquine phosphate, USP, is a 4-aminoquinoline compound for oral administration. It is a white, odorless, bitter tasting, crystalline substance, freely soluble inwater. Chloroquine phosphate tablets are an antimalarial and amebicidal drug.

     
  8. koby84 Well-Known Member

    Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Plaquenil Uses, Dosage & Side Effects - What drug company makes your Generic plaquenil? Hidroxicloroquina Wallpaper Iar
     
  9. Podkovka Guest

    Please make sure that Javascript and cookies are enabled on your browser and that you are not blocking them from loading. Hydroxychloroquine Side Effects Common, Severe, Long Term. Hydroxychloroquine Side Effects, Dosage, Uses, and More RA and Hydroxychloroquine How Effective is it for Rheumatoid Arthritis.
     
  10. Velin Dobrev XenForo Moderator

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    HYDROXYCHLOROQUINE - ORAL Plaquenil side effects.