In Sjögren’s, Plaquenil is used to treat many symptoms of Sjögren’s including fatigue, joint symptoms of arthritis and arthralgias (joint pain), dry mouth and dry eyes. Similar to its use in systemic lupus erythematosus, many clinicians feel that it is useful in reducing general Sjögren’s “disease activity.” One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. How does chloroquine phosphate work Effect of plaquenil on eyes Plaquenil bruising Hydroxychloroquine pigmentation Sep 15, 2014 Hydroxychloroquine sulfate is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions, with less toxic effects than chloroquine. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Stop taking hydroxychloroquine and call your doctor at once if you have trouble focusing, if you see light streaks or flashes in your vision, or if you notice any swelling or color changes in your eyes. Call your doctor at once if you have End stage hydroxychloroquine toxicity leads to widespread RPE and retinal atrophy with a loss of central vision, peripheral vision, and night vision. Recent studies have shown that patients of Asian descent develop initial damage in a more peripheral extramacular distribution near the arcades, most frequently in the inferotemporal region with corresponding superonasal field defects. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. Hydroxychloroquine poisoning Hydroxychloroquine - Wikipedia, Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Chloroquine dose in liver abscess Nov 01, 2015 Hydroxychloroquine is metabolized and secreted by both the liver and the kidneys. Therefore, disturbed renal or hepatic function might reduce HCQ clearance and increase the propensity for toxicity. Older age may also be associated with increased risk of macular toxicity, possibly due to the pre-existence of age-related macular changes that might not allow for the identification of early signs of toxicity. Retinal Physician - Hydroxychloroquine Maculopathy An Update.. Hydroxychloroquine Plaquenil Toxicity and.. PLAQUENIL HYDROXYCHLOROQUINE SULFATE TABLETS, USP DESCRIPTION. Call a poison control center at once and then seek emergency medical attention if you think you have used too much of this medicine. An overdose of hydroxychloroquine can be fatal, especially in children. Take hydroxychloroquine for the full prescribed length of time for malaria. Your symptoms may improve before the infection is completely cleared. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes. AT A GLANCE • Long-term use of hydroxychloroquine sulfate may result in parafoveal retinal toxicity. • No single imaging platform can confirm the presence of hydroxychloroquine toxicity. • Microperimetry and adaptive optics are undergoing studies to confirm their usefulness in.