Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Plaquenil ophthalmic side effects Plaquenil similar Chloroquine sle Aug 14, 2017 Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis. Plaquenil is the brand name of hydroxychloroquine, a drug used to prevent or treat malaria. Plaquenil is also used for long-term treatment of autoimmune diseases such as rheumatoid arthritis RA and systemic lupus erythmatosis. The drug chloroquine has long been used to treat malaria, but it is not without side effects. Chloroquine kills malaria by causing the pH in certain parts of the parasite's cell to increase, preventing important biochemical reactions. Unfortunately, excessive use of the drug can be toxic to humans too. Cardiac Effects Cases of cardiomyopathy resulting in cardiac failure, in some cases with fatal outcome, have been reported in patients treated during long term therapy at high doses with Chloroquine see ADVERSE REACTIONS and OVERDOSAGE. Monitor for signs and symptoms of cardiomyopathy and discontinue Chloroquine if cardiomyopathy develops. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine side effects long term Chloroquine Oral Uses, Side Effects, Interactions., Chemists expose side effects of antimalarial drug -- ScienceDaily Aao recommendations for plaquenil dosingPlaquenil macular edema Sep 13, 2019 Some side effects of hydroxychloroquine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Hydroxychloroquine Side Effects Common, Severe, Long Term.. Chloroquine - FDA prescribing information, side effects.. Chloroquine Side Effects Common, Severe, Long Term.. Symptoms of overdose. Cold, clammy skin. decreased urine. drowsiness. dry mouth. fast, weak pulse. increased thirst. lightheadedness, dizziness, or fainting. loss of appetite. muscle pain or cramps. numbness or tingling in the hands, feet, or lips. Tell your doctor if any of the following side effects become severe or don't go away Loss of appetite. Mild dizziness. Mild diarrhea. Clumsiness. Mild headache. Nausea or stomach cramps. May 23, 2019 Some side effects of primaquine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.