In a large, case-control study of elderly patients, those who used corticosteroids and NSAIDs concurrently had an estimated relative risk (RR) for peptic ulcer disease and GI hemorrhage of 14.6 compared to those who used neither. Oral corticosteroid use was associated with a doubling of the risk (estimated RR = 2.0), but the risk was confined to those who also used NSAIDs. Combine ibuprofen and hydroxychloroquine Plaquenil getting immune Summary Drug interactions are reported among people who take Prednisone and Hydroxychloroquine sulfate together. This study is created by eHealthMe based on reports of 3,854 people who take Prednisone and Hydroxychloroquine sulfate from Food and Drug Administration FDA, and is updated regularly. If you will be taking this medicine for a long time, it is very important that your doctor check you at regular visits for any unwanted effects that may be caused by this medicine. Blood or urine tests may be needed to check for unwanted effects. Using this medicine while you are pregnant can harm your unborn baby. When my wife was first diagnosed with PMR in May, 2016, she was put on 15mg Pred. A month later, she was told to take 400mg of plaquenil daily, with the understanding that plaquenil would replace prednisone eventually. This rheumy tried to get her down to 5mg six months later, which was a total mistake. MANAGEMENT: Caution is advised if oral corticosteroids and NSAIDs are used together, especially in patients with a prior history of peptic ulcer disease or GI bleeding and in elderly and debilitated patients. It is possible that both categories of agents are ulcerogenic and have additive effects on the GI mucosa during coadministration. Some investigators have also suggested that the primary effect of corticosteroids in this interaction is to delay healing of erosions caused by NSAIDs rather than cause de novo ulcerations. Can i take prednisone and hydroxychloroquine together Plaquenil Oral Interactions with Other Medication, Prednisone Oral Route Precautions - Mayo Clinic Chloroquine protein synthesisCan you get pregnant on plaquenil I wait at least 20 minutes and take 20 mg of Prilosec then eat more cereal/crackers and take the 7.5 Meloxicam. I take the second 7.5 after dinner. The doctor also has me on Vit D/Calcium as prolonged use of Prednisone can contribute to the development of steroid-induced osteoporosis. Can I take 15mg meloxicam and 5mg prednisone together?. Plaquenil? I have been on prednisone for 15 months. - PMRGCAuk. Prednisone and plaquenil -. Drug interactions are reported among people who take Prednisone and Plaquenil together. This study is created by eHealthMe based on reports of 13,794 people who take Prednisone and Plaquenil from Food and Drug Administration FDA, and is updated regularly. On eHealthMe, you can evaluate side effects and drug interactions from 16 million FDA. I take both prednisone and plaquenil. I heard someone once say that prednisone is the drug one loves to hate. It really does wonders to control inflammation, but has nasty side effects when given in large doses and/or used for a long period of time. My first experience with prednisone was horrific I was on 60mg per day, then on to 50, then 40. Does Prednisone Interact with other Medications? Severe Interactions. These medications are not usually taken together. Consult your healthcare professional e.g. doctor or pharmacist for more.