In particular, chloroquine and hydroxychloroquine (Plaquenil) are two such medications, with the potential for retinal toxicity. Given that the retinal damage from these medications is largely irreversible, screening by a retinal specialist is critical to detect early retinal toxicity to try and limit the extent of visual loss. Plaquenil and cataracts Plaquenil skin discoloration Like all medicines, it can cause side effects. Hydroxychloroquine retinopathy. It is known that some people who take. hydroxychloroquine for more than five years and/or in high doses are at increased risk of. damage to their retina, the light sensitive layer of cells at the back of the eye. This is known as. retinal toxicity or retinopathy. It’s rare for side effects to occur with Plaquenil if the medication is dosed properly Side effects Blurred vision, bull’s eye maculopathy, scotoma, vortex keratopathy, headache, accommodative dysfunction, whitening of eyelashes, phototoxicity3 The American Academy of Ophthalmology has published several dosing and screening recommendations for hydroxychloroquine to avoid potential retinal toxicity, yet some patients still experience permanent vision loss resulting from hydroxychloroquine retinopathy due to improper dosing of the drug and improper screening. A study by Wolfe and Marmor of 4000 patients with rheumatoid arthritis and systemic lupus erythematosus treated with hydroxychloroquine found a prevalence of 6.8/1000 patients. Recent studies suggest a higher prevalence of hydroxychloroquine retinal toxicity than previously recognized. Layers of retina affected with plaquenil Retinal Screening for Hydroxychloroquine Plaquenil Toxicity., Early Plaquenil Toxicity Detected without Bull’s Eye Maculopathy Hydroxyl chloroquineHydroxychloroquine 200 mg priceHydroxychloroquine for sle Damage to their retina, the light sensitive layer of cells at the back of the eye. This is known as retinal toxicity or retinopathy. Overall, around seven patients out of every 100 taking hydroxychloroquine for more than five years may develop retinopathy that can be detected with specialised tests. The risk is much higher in patients who have been Eye screening for patients taking hydroxychloroquine Plaquenil. Despite Plaquenil dosing recommendations, retinal toxicity.. How to Succeed in Plaquenil Screenings. People with lupus can get retinal vasculitis, which limits the blood supply to the retina, which can have significant effects on vision. The eye then attempts to repair itself, but when the retina tries to repair itself it forms new blood vessels which can form in areas of the eye that can impair vision. Effects of chronic exposure to hydroxychloroquine or chloroquine on inner retinal Lond 2010;0–6. Xiaoyn MA, Dongyi HE, Linping HE. Assessing chloroquine toxicity in RA patients using retinal nerve fibre layer thickness, multifocal electroretinography and visual field test. Side effects associated with Plaquenil are placed in three categories common, less common, and rare. If you have any of the following effects and they persist or worsen, notify your doctor or pharmacist promptly.