Even then we often have our symptoms treated long before they feel confident in making a Lupus diagnosis. all lupus type blood testing has came back negative as well two skin biopsies. People often have some intestinal issues when first starting plaquenil - things generally settle down in a few days. Also, it's good to have at least a few bites of food with it. It takes a rheumotologist to completely diagnose and treat Lupus. Lupus medicine plaquenil Hydroxychloroquine diagnostic studies Chloroquin malaria Hydroxychloroquine plaquenil ra Yes, plaquenil is difficult to adjust first, but after the first year of treatment and side effects, the benefits outweigh the problems. So, stick with it. In my opinion, the plaque nil is keeping the immune system regulated and the pain and other symptoms described will reduce. I've been on plaquenil for at least 15 years and from what i can remember it took about 6 months before i realized it was helping. now the best way to tell if its helping me is if i stop taking it, then i can REALLY tell. the pain is much worse along with the fatigue. plaquenil doesn't make it all go away but if i don't take it, it all comes. If you started with generic levothyroxine, you’ll not only want to keep taking the generic, but the generic made by the same manufacturer — your pharmacist can help you with that. 2 Your weight has changed quite a bit. As with most medications, if you’ve gained or lost weight, you may need to adjust the dosage of your thyroid medication. Or, like Lynnwood said, a doctor may try us on a medication to see if our response to it is diagnostically useful. I have sun induced rashes and painful hip joints and burning in the very low back area. Also, is intestinal distress a side effect of plaquenil?? What can plaquenil do to you if taken wrong Has anyone experienced plaquenil toxicity with damage to eyes?, Plaquenil.long do I have to wait? DailyStrength Plaquenil to treat ankylosing spondylitis Changing diet for days beforehand then trying to keep down the liquid prep and stay near the loo and keep sane. Only once I managed to drink as much as the guide book says and didn't throw up more than about twice. Which in itself is a lesson - drink as much clear liquid as you possibly can. Lemonade is fine. Gastroscopy, have to stop medication 10 days before? - UK.. Things That Can Mess With Your Thyroid Medication - GoodRx. Methotrexate and Plaquenil OK taken together? - HealthBoards. Aug 29, 2014 Plaquenil, hydroxychloroquine HCQ, is an anti-malarial medication that has been proven to be useful in the treatment of patients with rheumatoid arthritis RA, systemic lupus erythematosus SLE and other inflammatory and autoimmune diseases. In Sjögren’s, Plaquenil is used to treat many symptoms. So you'd be hitting two or three things at once with a doxy/plaquenil combination. Plaquenil is also pretty well tolerated by most people. Maybe the worst symptom I had until I had to stop due to visual disturbances – rare! was some gastrointestinal discomfort, but it was tolerable, all in all, and I don't think everyone is affected that way. I started plaquenil 200mg in the morning with breakfast and 200mg at night. My side effects were loss of appetite and nervousness/jittery, like anxiety. My side effects resolved after a few weeks. These days I tolerate plaq so well that I take 400mg once a day at night now. It's a great drug if you can work through the initial side effects.