Chloroquine is now uncommonly used in favor of its derivative hydroxychloroquine. In the United States, hydroxychloroquine is most often used for its anti-inflammatory effects in rheumatology and dermatology. What is in hydroxychloroquine Hydroxychloroquine abuse Later in the disease, patients can develop a bilateral bull's eye maculopathy, characterized by a ring of retinal pigment epithelium RPE depigmentation in the macula, sparing the fovea, which is often accompanied by paracentral and central scotomas. End stage hydroxychloroquine toxicity leads to widespread RPE and retinal atrophy with a loss. Bull’s eye maculopathy, a classic feature of advanced hydroxychloroquine toxicity. 3 months after medication was stopped, the patient’s visual acuity had remained stable, and no other complaints were reported. Hydroxychloroquine is an antimalarial drug commonly used in the treatment of systemic lupus erythematous, Plaquenil Toxicity - Bulls Eye Maculopathy 420 views 70-year-old woman with systemic Lupus erythematosus and clotting problems. She was on the Plaquenil for about eight years and then off the Plaquenil for the last eight years because she developed macular toxicity. While early toxicity may be asymtomatic, patients with more advanced stage of toxicity may complain of color vision changes or paracentral scotomas. Its toxic effects on the retina are seen in the macula. Bull's eye maculopathy hydroxychloroquine Drug induced maculopathy by Dr Jay Chhablani, Hydroxychloroquine-induced bull's eye maculopathy Saltwater fish chloroquine compatible with acriflavinePlaquenil ands ex drive Hydroxychloroquine Maculopathy An Update on Screening and Diagnosis A brief guide for imaging SHIRI SHULMAN, MD. H ydroxychloroquine HCQ; Plaquenil, Sanofi, Bridgewater, NJ is an antimalarial agent that is also commonly used as a treatment for a variety of rheumatologic and dermatologic conditions, such as rheumatoid arthritis and systemic lupus erythematosus. Retinal Physician - Hydroxychloroquine Maculopathy An.. Plaquenil Toxicity - Bulls Eye Maculopathy - Retina.. Retinal toxicity associated with chronic exposure to.. Bull’s Eye Maculopathy Hydroxychloroquine Toxicity or Macular Dystrophy? Posted by D. Poposka, A. Aranda Yus, B. Hayik and L. Broc Itturalde on Oct 1, 2008 in Macular Dystrophy Comments Off on Bull’s Eye Maculopathy Hydroxychloroquine Toxicity or Macular Dystrophy? Vázquez-Dorrego XM, Ruiz-Bilbao SM, Poposka D, Aranda-Yus A, Hayik B. Benign concentric annular macular dystrophy BCAMD is initially characterized by parafoveal hypopigmentation and good visual acuity, but progresses to a retinitis pigmentosa RP-like phenotype with a bull's eye configuration van Lith-Verhoeven et al. 2004. Hydroxychloroquine or chloroquine ingestion can cause atrophy of the retinal pigment epithelium in the form of a bull’s eye maculopathy in cases of chronic use. Early detection of toxicity prior to the development of the bull’s eye is important, as loss of visual acuity is usually irreversible at that stage.