Affecting my self esteem Your definitely not alone. I’m fair hair n skin but I’m getting brown blotches. I am not looking to when it starts coming down my face hope I can b helped in time. Plaquenil lymph nodes Chloroquine autophagic flux Molecular weight of chloroquine phosphate Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. The New Zealand Dermatological Society recommends that to decrease the risk of retina damage, no more than 200mg of Plaquenil should be taken a day, and a dose of 400mg per day should be taken no longer than a few weeks. I have been on Plaquenil for two years for RA, for which it has been great apart from a bit of itchiness, which I've mentioned elsewhere on this site in reply to another member asking about this. But lately the skin on my arms looks a bit blotchy. By this I mean that there are numerous small whiter-coloured circles whiter than the surrounding skin, anyway, almost like scars, or rather like. Plaquenil comes in 200 milligram mg tablets that are taken by mouth. To prevent malaria in adults, two tablets are typically taken once a week, on the same day each week. My scalp has turned black and my forehead side of face r slowly turning ears r totally black shiny plate .various long and boring treatments from docs but to no avail.finally I have been asked to stopped taking h for lupus for 3 next step will b decided. I am surprised to hear about this cos my rheumy said hydroxy helps to lighten the skin. One of them is on my nose and people keep telling me I’ve a dirt mark. I'm from Indian sub continent and am a "woman of colour like urself" approx 2 years ago had sudden deep painful itch in scalp and body. Yes I have been on this med since 2003 and I have black patches all over. Plaquenil dark spots Common and Rare Side Effects for Plaquenil Oral, Plaquenil and 'white patches' on my skin? - Inspire Chloroquine phoaphate powderFaf plaquenil screening What are the side effects of Plaquenil? The most common side effects are diarrhea, nausea, vomiting, headache, dizziness, skin rash or black spots when you look at things. Most side effects will go away when your body gets used to the medicine. Tell your doctor if you have these side effects. Lupus Medicines Hydroxychloroquine - Brigham and Women's.. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Plaquenil and spots on skin DailyStrength. Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Plaquenil can cause pigment discolouration in the skin. I have two darker patches on the sides of my face which developed quite some time after taking it. It sort of looks like parts of my face are in the shade It might be the cause of your brown spots as well? I also notice that the skin affected feels rougher as well.