But Chloroquine has significantly higher rate of retinal toxicity, so it isn't used much anymore. Also, Plaquenil appears to effectively reduce flares in patients with lupus not necessarily by suppressing immunity. Read more Anxiety over potential eye problems with Hydroxychloroquine is completely unwarranted if the dose is kept below 6mg/kg (2.2lbs) of body weight. Read more See 1 more doctor answer It can cause eye problems so you need to see an ophthalmologist and peridoic screenings. Read more Results are very good, particulary when used alone and better with methotrexate. Chloroquine interactions Endometriosis plaquenil I've had mild to moderate Lupus since 1986. Have no organ involvement. I became allergic to aspirin and Ibuprofen, etc. so can no longer take them. When I take Plaquenil which I had been on for years I now get a rash and it makes my asthma act up. I need something for inflammation but what do people take instead of NSAIDS or Plaquenil for. Alternatives to Methotrexate self.lupus submitted 4 hours ago by auscientist. I have a long list of medication that I am allergic to including NSAIDs and plaquenil. A few years ago at the time she finally had enough evidence to call lupus not zero-negative RA we tried methotrexate. Plaquenil changes the way your immune system works. In some kinds of lupus, your immune system attacks your body instead of protecting it. Plaquenil tries to quiet or slow down the immune system. Chloroquine can be substituted for Plaquenil but only in limited circumstances. Please provide more detailed information if you want a more specific answer. Read more See 1 more doctor answer Depends on what you are being treated for.... Read more While plaquenyl is a slow acting but effective drug, Prednisone is used in much higher doses in active sle. Arthritis (non-deforming) or arthralgias associated with the disease will have substantial pain relief with a dose this low. It's infusion intervals are longer, because the turnover of recptors is slower than the production of tnf-a itself. So other meds like Imuran and Cell Cept (mycophenolate mofetil) also reduce flares, but also increases infection. Read more It depends why you are taking Plaquenil in the first place. Apart from some stomach quiziies, I have never stopped this drug, as long as it demonstrated it is working. Other than that we see a few people who have increased skin pigmentation called "plaquenil ochronosis". The dirrence with Remicade (infliximab) is that it blocks the tnf-a receptor, rather than binding tnf-a itself, but it accomplishes the same thing. I have lupus am allergic to plaquenil substitute Treating Lupus with Anti-Malarial Drugs Johns Hopkins., Alternatives to Methotrexate lupus Hydroxychloroquine medline plus May 20, 2008 May be I've asked this question before in some other form, but I really would like to know if there is an alternative to Plaquenil. Plaquenil was the only drug for me which gave me instantaneous better saliva flow + improved my depression within a week. Is there an alternative to Plaquenil?. Lupus Medicines Hydroxychloroquine - Brigham and Women's.. Plaquenil when allergic to sulfa? Lupus Forums at The Lupus Site. Sep 20, 2019 C-Quinicrin is an alternative to Plaquenil that worked REALLY well for me. The last I heard it was no longer in the US, so I have been been without it and feel miserable. Has anyone found a way to buy it in Canada or elsewhere. I am hurting here in California. I cannot take Plaquenil. Back in April i started to take the Brand Plaquenil because I am allergic to Sulfa. I had read that it was better to take the Brand if you were allergic to Sulfa. And thank goodness, I have done well with it so far. I was started on a small dose, 1\2 tablet a day, but now the Rheumie wants me to take 400 mg a day. I have cutaneous lupus. I was dx in August with Lupus and my Rheumy said she was afraid to start me on Plaquenil since I had a bad reaction to a Sulfa antibiotic I took and the same reaction when a Dr gave me Lasix. I read that the sulfa in Plaquenil is different from those in antibiotics and most people with Lupus have an allergy to Sulfa but can take Plaquenil without any problems.