Additionally, another exception occurred while executing the custom error page for the first exception. Ototoxicity is, quite simply, ear poisoning (oto = ear, toxicity = poisoning), which results from exposure to drugs or chemicals that damage the inner ear or the vestibulo-cochlear nerve (the nerve sending balance and hearing information from the inner ear to the brain). Chloroquine phosphate oral dosage Plaquenil classificatin Can plaquenil be taken with neurontin Antimalarials- Quinine & Chloroquine- Ototoxic effect is due to vasoconstriction in the small vessels of the cochlea and stria vascularis.- The effect is reversible which generally appears on prolonged medication, but deafness is permanent with chloroquine.- Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. Chloroquine should be used with caution in patients with neurological disease including preexisting hearing impairment or seizure disorder. Polyneuritis, ototoxicity, seizures, neuromyopathy, and acute extrapyramidal symptoms dystonia, dyskinesia, tongue protrusion, torticollis have occurred with chloroquine therapy. The parts of the brain that receive hearing and balance information from the inner ear can also be affected by poison, but this is not technically considered ototoxicity and won’t be covered in this information sheet. Because the inner ear is involved in both hearing and balance, ototoxicity can result in disturbances of either or both of these senses. Chloroquine ototoxicity Hydroxychloroquine-Induced Retinal Toxicity - American., Chloroquine - Wikipedia Azathioprine and plaquenilCan chloroquine abortWill plaquenil affect drug test Chloroquine is related chemically to quinine and, because of this similarity, has been suspected of being an ototoxic drug. 1 It is currently being used for the treatment of malaria, amebiasis, rheumatoid Ototoxicity of Chloroquine JAMA Otolaryngology–Head & Neck.. Chloroquine Phosphate chloroquine phosphate dose.. Chloroquine and Hydroxychloroquine Toxicity Practice.. Chloroquine is related chemically to quinine and, because of this similarity, has been suspected of being an ototoxic drug.1 It is currently being used for the treatment of malaria, amebiasis. The present study provides the first evidence for the occurrence of autophagy and its role in cisplatin-induced ototoxicity. In conclusion, autophagy plays a pro-death role in cisplatin-induced ototoxicity via mTOR pathway, and modulating the autophagic pathway might be another strategy against cisplatin-induced ototoxicity. Conclusions Chloroquine is not significantly ototoxic when administered in regular doses for treatment of uncomplicated malaria. The ototoxic effects of chloroquine which are rarely encountered are fully reversible. Keywords ototoxicity, chloroquine, malaria. I. Introduction hloroquine is a drug with wide spread clinical applications.