Chloroquine ototoxicity

Discussion in 'Northwest Pharmaceuticals Canada' started by jokerov, 15-Mar-2020.

  1. Medvet New Member

    Chloroquine ototoxicity


    Additionally, another exception occurred while executing the custom error page for the first exception. Ototoxicity is, quite simply, ear poisoning (oto = ear, toxicity = poisoning), which results from exposure to drugs or chemicals that damage the inner ear or the vestibulo-cochlear nerve (the nerve sending balance and hearing information from the inner ear to the brain).

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    Antimalarials- Quinine & Chloroquine- Ototoxic effect is due to vasoconstriction in the small vessels of the cochlea and stria vascularis.- The effect is reversible which generally appears on prolonged medication, but deafness is permanent with chloroquine.- Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. Chloroquine should be used with caution in patients with neurological disease including preexisting hearing impairment or seizure disorder. Polyneuritis, ototoxicity, seizures, neuromyopathy, and acute extrapyramidal symptoms dystonia, dyskinesia, tongue protrusion, torticollis have occurred with chloroquine therapy.

    The parts of the brain that receive hearing and balance information from the inner ear can also be affected by poison, but this is not technically considered ototoxicity and won’t be covered in this information sheet. Because the inner ear is involved in both hearing and balance, ototoxicity can result in disturbances of either or both of these senses.

    Chloroquine ototoxicity

    Hydroxychloroquine-Induced Retinal Toxicity - American., Chloroquine - Wikipedia

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  5. Chloroquine is related chemically to quinine and, because of this similarity, has been suspected of being an ototoxic drug. 1 It is currently being used for the treatment of malaria, amebiasis, rheumatoid

    • Ototoxicity of Chloroquine JAMA Otolaryngology–Head & Neck..
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    Chloroquine is related chemically to quinine and, because of this similarity, has been suspected of being an ototoxic drug.1 It is currently being used for the treatment of malaria, amebiasis. The present study provides the first evidence for the occurrence of autophagy and its role in cisplatin-induced ototoxicity. In conclusion, autophagy plays a pro-death role in cisplatin-induced ototoxicity via mTOR pathway, and modulating the autophagic pathway might be another strategy against cisplatin-induced ototoxicity. Conclusions Chloroquine is not significantly ototoxic when administered in regular doses for treatment of uncomplicated malaria. The ototoxic effects of chloroquine which are rarely encountered are fully reversible. Keywords ototoxicity, chloroquine, malaria. I. Introduction hloroquine is a drug with wide spread clinical applications.

     
  6. MaxterProfi New Member

    Chloroquine retinopathy, is a form of toxic retinopathy (damage of the retina) caused by the drugs chloroquine or hydroxychloroquine, which are sometimes used in the treatment of autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus. Incidence of and risk factors for chloroquine and hydroxychloroquine. Chloroquine retinopathy - Wikipedia Hydroxychloroquine and Chloroquine Retinopathy.
     
  7. vvovann User

    Plaquenil.long do I have to wait? DailyStrength I know I've asked this question before, but with so many new people and so much time that's passed, I thought I'd ask again. How long did it take for Plaquenil to become effective for you? Meaning, when did you start to feel some relief from your lupus symptoms after you started taking.

    Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses
     
  8. MrX XenForo Moderator

    How Does Plaquenil Work For Rheumatoid Arthritis Autoimmune diseases, like rheumatoid arthritis and lupus, are linked. Facts for patients and caregivers about the DMARD drug Hydroxychloroquine Plaquenil such as usages, Today, it is used to treat rheumatoid arthritis, Discover the 5 Common Signs and Symptoms of Rheumatoid Arthritis.

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