Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. How does hydroxychloroquine kill malaria Act chloroquine Plaquenil and ankylosing spondylitis Adults. 200 mg 155 mg base to 400 mg 310 mg base PO per day, administered as a single dose or in 2 divided doses. Antimalarials and/or glucocorticoids are of benefit and may be used for the treatment of SLE without major organ manifestations; however, judicious use of hydroxychloroquine is recommended. A cumulative dose of 1000g of hydroxychloroquine or 460g of chloroquine was likely the largest risk factor, which was typically achieved after 5-7 years of a typical dosage 8, 10. However, there have been case reports of patients with hydroxychloroquine toxicity as early as 1.9 months after starting treatment 11. Typical starting dose is 800 mg. This is followed by 400 mg three times 6 hours after the first dose, 24 hours after the first dose, and 48 hours after the first dose. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil normal dosage Plaquenil Oral Uses, Side Effects, Interactions., Hydroxychloroquine Plaquenil Toxicity and. Herpes and plaquenilPlaquenil and swollen eyes Mg/kg base not to exceed 400 mg 310 mg base PO weekly, starting 2 weeks before exposure and continued for 4 weeks after departure from area With prolonged therapy, obtain CBCs periodically. Plaquenil hydroxychloroquine sulfate dosing, indications.. Hydroxychloroquine Side Effects, Dosage, Uses, and More. Hydroxychloroquine Uses, Dosage & Side Effects -. The first dose of Plaquenil is usually taken one to two weeks before traveling to an area where malaria is prevalent. Doses are then continued for four weeks after exposure. Apr 10, 2019 To treat malaria Plaquenil is usually given for 3 days, starting with one high dose followed by a smaller dose during the next 2 days in a row. Take Plaquenil for the full prescribed length of time for malaria. Your symptoms may improve before the infection is completely cleared. Patients in this new study 2 mostly had been prescribed routine doses of HCQ by prior standards, but the average use was approximately 5.0 mg/kg of real weight because of varying compliance and body habitus.