Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Plaquenil withdrawal Plaquenil depression What is hydroxychloroquine used to treat Plaquenil no appetite Rheumatoid Arthritis. The action of hydroxychloroquine is cumulative and may require weeks to months to achieve the maximum therapeutic effect see CLINICAL PHARMACOLOGY. Initial adult dosage 400 mg to 600 mg 310 to 465 mg base daily, administered as a single daily dose or in two divided doses. Neutropenia is a decrease in circulating neutrophils in the nonmarginal pool, which constitutes 4-5% of total body neutrophil stores. Most of the neutrophils are contained in the bone marrow, either as mitotically active one third or postmitotic mature cells two thirds. Overdose. Hydroxychloroquine is very toxic in overdosage; overdosage is extremely hazardous and difficult to treat. Urgent advice from the National Poisons Information Service is essential. Life-threatening features include arrhythmias which can have a very rapid onset and convulsions which can be intractable. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Neutropenia hydroxychloroquine Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus, Neutropenia Practice Essentials, Background, Pathophysiology Effects of plaquenil on eyes Hydroxychloroquine is classified as an anti-malarial drug. It is similar to chloroquine Aralen and is useful in treating several forms of malaria as well as lupus erythematosus and rheumatoid arthritis. Its mechanism of action is unknown. Malarial parasites invade human red blood cells. Hydroxychloroquine Plaquenil Side Effects & Dosage for.. HYDROXYCHLOROQUINE SULFATE Drug BNF content published.. Hydroxychloroquine - Wikipedia. Neutropenia in Felty's syndrome successfully treated with hydroxychloroquine. Mahévas M1, Audia S, De Lastours V, Michel M, Bonotte B, Godeau B. Plaquenil is not effective against chloroquine or hydroxychloroquine-resistant strains of Plasmodium species see CLINICAL PHARMACOLOGY – Microbiology. Plaquenil is not recommended for the treatment of malaria acquired in geographic areas where chloroquine resistance occurs or when the Plasmodium species has not been identified. Neutropenia in Felty’s syndrome successfully treated with hydroxychloroquine. hydroxychloroquine. for the treatment of severe neutropenia due to Felty's syndrome FS or systemic lupus.