The clinical trials on this list are studying Hydroxychloroquine. NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. Plaquenil and itching Chloroquine resistance characteristics Plaquenil and constipation Mechanism plaquenil The pharmacological profile of chloroquine and hydroxychloroquine, however, appear to involve mechanisms other than autophagy inhibition. Here, we discuss the dual role of autophagy in oncogenesis and tumor progression, and summarize the results or design of clinical studies recently completed or initiated to evaluate the therapeutic activity of chloroquine derivatives in cancer patients. Chloroquine CQ and hydroxychloroquine HCQ, two antimalarial drugs, are suggested to have potential anticancer properties. in the present study, we investigated the effects of CQ and HCQ on cell growth of bladder cancer with emphasis on autophagy inhibition and apoptosis induction in vitro. Objective To assess the efficacy of chloroquine Aralen phosphate and hydroxychloroquine Plaquenil sulfate in the treatment of patients with neurosarcoidosis who either do not respond to corticosteroid therapy or develop unacceptable side effects. Design Retrospective study. Setting. Talk to your doctor for help in deciding if one is right for you. You may want to think about taking part in a clinical trial. Chloroquine and hydroxychloroquine in cancer therapy Hydroxychloroquine Uses, Dosage & Side Effects -, Chloroquine and hydroxychloroquine inhibit bladder cancer cell growth. How does chloroquine work at the cellular levelHydroxychloroquine sulfate coupon Chloroquine has been used for many years to treat patients with malaria, lupus, and rheumatoid arthritis, but more recently, hydroxychloroquine has been evaluated as a treatment for pancreatic cancer, with encouraging preliminary results. Chloroquine reduces hypercoagulability in. - BMC Cancer. Effectiveness of Chloroquine and Hydroxychloroquine in Treating.. Repurposing Drugs in Oncology ReDO—chloroquine and.. Cesses of autophagy is a more preferable approach in cancer therapy, however, and is now under investigation 28. Chloroquine in the Kidney, the Double-Edged Sword of Autophagy The use of chloroquine in combination with other chemo-therapeutic reagents may enhance cancer treatment 8, 29, but normal cells also use autophagy to maintain homeostasis, As an essential evolutionary catabolic process of cytoplasmatic component digestion, it is generally believed that modulating autophagic activity, through targeting specific regulatory actors in the core autophagy machinery, may impact disease processes. The process of finding new therapeutic indications for currently used drugs, defined as ‘repurposing’, is receiving growing attention. Chloroquine and hydroxychloroquine, with an original indication to prevent or cure malaria, have been successfully used to treat several infectious HIV, Q fever, Whipple’s disease, fungal infections, rheumatological systemic lupus erythematosus.