Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Hydroxychloroquine sulphate and pregnancy Does prednisone and plaquenil work for ankylosing spondylitits Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. Otrexup methotrexate is the first-choice treatment for many types of cancer and arthritis, but it has many side effects. Hello hope everyone is well just a quick question, i have been on methotrexate for 2 months increasing from 7.5 to 15 and now to 25mg.weekly now been given plaquenil 400mg daily, has anyone else been on this mixture and has it worked or how long should i wait to see if it works. The AUC of HCQ showed no significant difference p = 0.957 between any of the dosing occasions. CONCLUSION These results may explain the increased potency of the MTX-HCQ combination over MTX as a single agent and also the sustained effects of MTX when administered with HCQ. Recently my eyes have felt sore and, after posting a question on this site, I am seeing my GP on Monday. Thanks Hi Catjones I have been taking this combination, started on both of them in January this year. Difference between methotrexate and plaquenil Evaluation of efficacy of combination of methotrexate and., Methotrexate and plaquenil - Chloroquine and beclinJoint task force-bravo chloroquine 1989How to switch from plaquenil to methotrexateJc virus and plaquenilHow good is plaquenil for diabetes Plaquenil is best taken with a meal as otherwise it may cause nausea. methotrexate is once a week usually and most of the side effects would hit the next day so some people choose to take it on a Friday or Saturday night and sleep through any potential side effects Plaquenil vs Methotrexate rheumatoid - reddit. Combination therapy with methotrexate and.. Side effects plaquenil/methotrexate. rheumatoid. Lung inflammation was not improving enough so Pulmonary Dr. and Rheumy increased plaquenil to 600 mg and 60 mg of predisone. I continued to have lung issues and was unable to reduce prednisone below 40mg without flare up so they added 17.5 mg of methotrexate. My prednisone dose is now down to alternating days of 20 mg/0mg. I was diagnosed with RA in march and have been on increasing dose of methotrexate. Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Thanks Hello thanks for your time. I started both of these ten weeks ago, I'm on 400mg hydroxy and 25mg of methotrexate. Last week I got in such a state about having to take them and it's got to a point where I constantly feel sick because I'm so anxious of having them, so I've been taken off hydroxychloroquine for two weeks so that now I only have medication on a Monday, I thought this would help.