Chloroquine retinopathy after drug cessation

Discussion in 'Generic Chloroquine' started by eXtravert, 23-Feb-2020.

  1. AEthiltkig New Member

    Chloroquine retinopathy after drug cessation


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    Delayed-onset chloroquine retinopathy was diagnosed in a patient seven years after cessation of treatment by a total dose of 730 g of chloroquine for rheumatoid arthritis. Visual functions. A differential diagnosis of chloroquine retinopathy includes retinitis pigmentosa. After the cessation of long-term chloroquine administration, pigmentary clumping or pigment epithelial hyperplasia may be observed in the retinal periphery. Abstract. Published case reports of chloroquine retinopathy rarely include details of daily dosage, but 30 reports where this information was available included 78 patients who developed impaired visual acuity an 13 had received daily doses of 250 mg or less.

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Chloroquine retinopathy after drug cessation

    Chloroquine retinopathy - Wikipedia, Chloroquine retinopathy and secondary trauma - ScienceDirect

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  5. Oct 01, 2018 Radioactively tagged Chloroquine administered intravenously to pregnant pigmented CBA mice passed rapidly across the placenta and accumulated selectively in the melanin structures of the fetal eyes. It was retained in the ocular tissues for five months after the drug had been eliminated from the rest of the body 2. There are no adequate and well-controlled studies evaluating the safety and efficacy of Chloroquine in pregnant women.

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    Prolonged exposure can allow the drug to accumulate in the retina, where it remains in the pigmented structures long after its use is stopped. In patients with retinopathy, traces of chloroquine have been found in plasma, erythrocytes, and urine 5 years or more after discontinuation of the drug. Long-Term Course of Chloroquine Retinopathy after Cessation of Medication - ScienceDirect JavaScript is disabled on your browser. Please enable JavaScript to use all the features on this page. Skip to main content Skip to article Importance Given the infrequent occurrence of hydroxychloroquine toxic effects, few data are available about the presenting features and long-term follow-up of patients with hydroxychloroquine retinopathy, making it difficult to surmise the clinical course of patients after cessation of drug treatment.

     
  6. cornelpros Guest

    Allergies occur when your immune system is triggered by envirionmental factors it should ignore--for example, pollen in the air, or dander on a cat or dog--and creates cells to fight against them. Lupus Medicines Hydroxychloroquine - Brigham and Women's. Hydroxychloroquine - Wikipedia Plaquenil, Plaquenil Sulfate, Quineprox hydroxychloroquine.
     
  7. romancher Guest

    The following information is NOT intended to endorse any particular medication. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus Plaquenil Drug and Medication User Reviews on RxList Plaquenil & Gabapentin - Lupus and Fibromyalgia" Lupus.
     
  8. pablito User

    Chloroquine Aralen - Side Effects, Dosage, Interactions - Drugs Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat.

    Chloroquine Retinopathy - an overview ScienceDirect Topics