Rural areas of Kalimantan (Borneo), Nusa Tenggara Barat (includes the island of Lombok), Sulawesi, and Sumatra. Low transmission in rural areas of Java, including Pangandaran, Sukabumi, and Ujung Kulong. Plaquenil and aplastic anemia Hydroxychloroquine ptsd Plaquenil reactive arthritis Oct 01, 2018 Chloroquine phosphate tablets are indicated for the Treatment of uncomplicated malaria due to susceptible strains of P. falciparum, P.malariae, P. ovale, and P.vivax. Prophylaxis of malaria in geographic areas where resistance to Chloroquine is not present. Treatment of extraintestinal amebiasis. Chloroquine, a 4-amino-quinoline, has been the backbone of antimalarial therapy and prophylaxis for 50 years. The incessant spread of resistance to chloroquine by P. falciparum is leading to a resurgence of malaria in most endemic areas. In India, chloro-quine resistance in P. falciparum was first reported by Manjha in the Karbi Anglong District in 1973 8 and from Nowgaon in 1974 in the northeastern state of Assam. More cases were detected in the next 3-4 years in Assam, Arunachal Pradesh, Mizoram, and Nagaland. Factors that affect local malaria transmission patterns can change rapidly and from year to year, such as local weather conditions, mosquito vector density, and prevalence of infection. None in the cities of Jakarta and Ubud, resort areas of Bali and Java, and Gili Islands and the Thousand Islands (Pulau Seribu). Chloroquine resistance in india Drug Resistance National Vector Borne Disease Control., Chloroquine - an overview ScienceDirect Topics Difference between methotrexate and plaquenilHydroxychloroquine and sulfasalazine combinationWho created chloroquineHydroxychloroquine in diabetes Chloroquine-resistant P. vivax malaria was first identified in 1989 among Australians living in or traveling to Papua New Guinea. P. vivax resistance to chloroquine has also now been identified in Southeast Asia, Ethiopia, and Madagascar. Isolated reports have suggested chloroquine-resistance P. vivax in other countries and regions, but further evaluation is needed. Drug Resistance in the Malaria-Endemic World. Burden of Malaria in India Retrospective. - NCBI Bookshelf. STUDY OF CHLOROQUINE RESISTANCE IN Plasmodium falciparum.. Within the 72 to 76 amino acid loci of P. falciparum chloroquine resistant transporter gene pfcrt, the chloroquine-sensitive CQS strains have been marked with CVMNK allele, while polymorphism within this locus conferring CQR is characterized by CVIET and CVIDT in parts of SEA and Indochina, respectively, SVMNT in Africa, and CVMNT in South America 16, 17. Malaria is a major public health problem in India, accounting for sizeable morbidity, mortality and economic loss. Apart from preventive measures, early diagnosis and complete treatment are the important modalities that have been adopted to contain the disease. Malaria epidemiology in India is believed to be affected by two major factors high genetic diversity and evolving drug resistance in P. falciparum. How transmission intensity of malaria can influence the genetic structure of chloroquine-resistant P. falciparum population in India is unknown.