You see, about two years I was diagnosed with one mixed connective tissue disorder. Good friend recommended me some Plaquenil drug for this and I was just wondering has anyone used it and what were the effects. I'm very sorry that you have developed this unpleasant condition. I had the plaque-type rash on upper arms, back and face. I talked with my sister about this because few years back she had the same problems like you now. Chloroquine hydrochloride Plaquenil monitoring guidelines Will my hair grow back after plaquenil Swelling is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years, also take medication Enbrel, and have Osteoporosis. Plaquenil can cause edema in the feet and legs. One of the warnings says to contact your doctor if you develop swelling/edema in the feet and legs. I had a medication cause me to retain fluid and I gained 6.5 pounds in 2 days. All of it was in my legs and feet. Lupus arthritis causes pain, stiffness, swelling, tenderness and warmth in your joints. The joints most often affected are the ones farthest from the middle of the body, such as fingers, wrists, elbows, knees, ankles and toes. General stiffness upon awakening, which gradually improves as the day goes on, is a key feature of lupus arthritis. It worked so well for her that she almost forgot she had the disease. I was using one drug and topical cream for my skin changes and it didn’t help that much. Just recently I started to notice that my feet began to swell. She was also using this Plaquenil and it has changed her life completely. Can plaquenil cause ankle swelling Rheumatoid Arthritis Swollen Feet & Ankles Atlanta, Please tell me about your swollen ankles/calves. Chloroquine resistance countriesChloroquine hallucinations how frequent Signs of heart problems, such as swelling of the ankles, shortness of breath, or an irregular heart rhythm arrhythmia Signs of an allergic reaction, such as An unexplained rash Plaquenil can cause severe, life-threatening rashes Hives ; Itching ; Unexplained swelling especially of the lips, mouth, or throat Wheezing or other breathing. When to Report Reactions to Plaquenil. How Lupus Affects the Muscles, Tendons and Joints Lupus.. Plaquenil Side Effects Common, Severe, Long Term -. There is no Foot, leg, and ankle swelling reported by people who take Plaquenil yet. This review analyzes which people have Foot, leg, and ankle swelling with Plaquenil. It is created by eHealthMe based on reports from Food and Drug Administration FDA, and is updated regularly. eHealthMe has been monitoring drugs since 2008. If you have had any eye changes or changes in eyesight due to Plaquenil hydroxychloroquine or drugs like this one. If you have psoriasis. If you have porphyria. If you are taking cimetidine. If you are taking any drugs that can cause a certain type of heartbeat that is not normal prolonged QT interval. There are many drugs that can do this. Rheumatoid arthritis RA is an autoimmune disease that causes chronic inflammation of the joints, the tissue around the joints, as well as other organs in the body. Because it can affect multiple other organs of the body, rheumatoid arthritis is referred to as a systemic illness and is sometimes called rheumatoid disease.