Synthesis of chloroquine phosphate slideshare

Discussion in 'Generic Chloroquine Online' started by fitty, 21-Feb-2020.

  1. Turing User

    Synthesis of chloroquine phosphate slideshare


    One of these ways consists of reacting 3-chloroaniline with ethoxymethylenmalonic ester to make (3-choroanilino)-methylenemalonic ester (37.1.1.4), which then undergoes high-temperature heterocyclization to make the ethyl ester of 7-chloro-4-hydroxyquinolin-3-carboxylic acid (37.1.1.5). Hydrolyzing this with sodium hydroxide gives 7-chloro-4-hydroxyquinolin-3-decarboxylic acid (37.1.1.6), which when heated at 250–270 C is decarboxylated, forming 7-chloro-4-hydroxyquinoline (37.1.1.7).

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    Visit the post for more. Chloroquine can inhibit a pre-entry step of the viral cycle by interfering with viral particles binding to their cellular cell surface receptor. Chloroquine was shown to inhibit quinone reductase 2, a structural neighbour of UDP-N-acetylglucosamine 2-epimerases that are involved in the biosynthesis of sialic acids. The sialic acids are acidic. How to use Chloroquine Phosphate. Take this medication by mouth, usually with food to prevent stomach upset, exactly as directed by your doctor. Daily or weekly dosing, dosage amount, and length.

    Alkaline hydrolysis of the ethyl ester of the 7-chloro-4-hydroxyquinolin-2-carboxylic acid (37.1.1.9) and subsequent high-temperature decarboxylation of the resulting acid (37.1.1.11) gives 7-chloro-4-hydroxyquinolin (37.1.1.7). Treating this with phosphorus oxychloride gives one of the desired components for synthesis of chloroquine – 4,7-dichloroquinoline (37.1.1.1) [The second method of preparing of 4,7-dichloroquinoline (37.1.1.1) consists of reacting 3-chloroaniline with the diethyl ester of oxaloacetic acid in the presence of acetic acid to give the corresponding enamine (37.1.1.8), which when heated to 250 °C undergoes heterocyclization to the ethyl ester of 7-chloro-4-hydrozyquinolin-2-carboxylic acid (37.1.1.9) accompanied with a small amount of 5-chloro-4-hydroxyquinolin-2-carboxylic acid (37.1.1.10), which is separated from the main product by crystallization from acetic acid.

    Synthesis of chloroquine phosphate slideshare

    New insights on the antiviral effects of chloroquine., New insights on the antiviral effects of chloroquine against.

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  4. Chloroquine Phosphate is the phosphate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. Although the mechanism of action is not fully understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase.

    • Chloroquine phosphate C18H32ClN3O8P2 - PubChem.
    • Chloroquine Phosphate - WebMD.
    • Antimalarial drugs -.

    Pharmacokinetics Synthetically available as chloroquine phosphate Rapidly and completely absorbed from GIT. Metabolised in liver. Peak conc. Achieved in 2-3 hrs after oral dose. High tissue distribution esp in liver, spleen,lung, kidney. t½ 3-4days but terminal t½1- 2months 4 5. Class antimalarial drugs. effective plasma conc. 600 mg of base stat 300 mg base after 8 hours 150 mg of base BD for 2 days 200 mg oral tablet of chloroquine phosphate consists of 150 mg base. erythrocytic schizonticide related to mefloquine MOA- similar to chloroquine -also affects nucleic acid and protein synthesis of parasite Fatty. Sigma-Aldrich offers a number of Chloroquine phosphate products. View information & documentation regarding Chloroquine phosphate, including CAS, MSDS & more.

     
  5. 555 User

    Are blood tests becoming the future of managing multiple sclerosis? Plaquenil and Hashimoto's - HealthBoards Plaquenil Hydroxychloroquine - Side Effects, Dosage. Hydroxychloroquine Side Effects, Dosage, Uses, and More
     
  6. Cursion Moderator

    Also known as: Plaquenil, Quineprox The following information is NOT intended to endorse any particular medication. Plaquenil - Lupus Hydroxychloroquine Plaquenil — Canadian Hair Loss Foundation Plaquenil Side Effects Of Bipolar And Depression.
     
  7. master-alfa New Member

    Anyone been treated with Plaquenil hydroxyc. - Vasculitis UK Hi, This is good to hear. I have suffered from urticarial vasculitis in the past and also have petechiae. I know that Plaquenil is used for vasculitis of the skin cutaneous, although not generally prescribed for more severe systemic types. Still, I would like to try plaquenil to see if it helps before taking something more toxic.

    Vasculitis and Lupus Lupus Foundation of America
     
  8. Rellikt Well-Known Member

    Plaquenil Hydroxychloroquine - Side Effects, Dosage. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as.

    Hydroxychloroquine Oral Uses, Side Effects, Interactions.