One of these ways consists of reacting 3-chloroaniline with ethoxymethylenmalonic ester to make (3-choroanilino)-methylenemalonic ester (220.127.116.11), which then undergoes high-temperature heterocyclization to make the ethyl ester of 7-chloro-4-hydroxyquinolin-3-carboxylic acid (18.104.22.168). Hydrolyzing this with sodium hydroxide gives 7-chloro-4-hydroxyquinolin-3-decarboxylic acid (22.214.171.124), which when heated at 250–270 C is decarboxylated, forming 7-chloro-4-hydroxyquinoline (126.96.36.199). Can tramadol and hydroxychloroquine be taken together Calcium chloroquine autophagy review Is hydroxychloroquine a sulfa drug Visit the post for more. Chloroquine can inhibit a pre-entry step of the viral cycle by interfering with viral particles binding to their cellular cell surface receptor. Chloroquine was shown to inhibit quinone reductase 2, a structural neighbour of UDP-N-acetylglucosamine 2-epimerases that are involved in the biosynthesis of sialic acids. The sialic acids are acidic. How to use Chloroquine Phosphate. Take this medication by mouth, usually with food to prevent stomach upset, exactly as directed by your doctor. Daily or weekly dosing, dosage amount, and length. Alkaline hydrolysis of the ethyl ester of the 7-chloro-4-hydroxyquinolin-2-carboxylic acid (188.8.131.52) and subsequent high-temperature decarboxylation of the resulting acid (184.108.40.206) gives 7-chloro-4-hydroxyquinolin (220.127.116.11). Treating this with phosphorus oxychloride gives one of the desired components for synthesis of chloroquine – 4,7-dichloroquinoline (18.104.22.168) [The second method of preparing of 4,7-dichloroquinoline (22.214.171.124) consists of reacting 3-chloroaniline with the diethyl ester of oxaloacetic acid in the presence of acetic acid to give the corresponding enamine (126.96.36.199), which when heated to 250 °C undergoes heterocyclization to the ethyl ester of 7-chloro-4-hydrozyquinolin-2-carboxylic acid (188.8.131.52) accompanied with a small amount of 5-chloro-4-hydroxyquinolin-2-carboxylic acid (184.108.40.206), which is separated from the main product by crystallization from acetic acid. Synthesis of chloroquine phosphate slideshare New insights on the antiviral effects of chloroquine., New insights on the antiviral effects of chloroquine against. What are symptoms of plaquenil eye problemsTablet chloroquine comment se present Chloroquine Phosphate is the phosphate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. Although the mechanism of action is not fully understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase. Chloroquine phosphate C18H32ClN3O8P2 - PubChem. Chloroquine Phosphate - WebMD. Antimalarial drugs -. Pharmacokinetics Synthetically available as chloroquine phosphate Rapidly and completely absorbed from GIT. Metabolised in liver. Peak conc. Achieved in 2-3 hrs after oral dose. High tissue distribution esp in liver, spleen,lung, kidney. t½ 3-4days but terminal t½1- 2months 4 5. Class antimalarial drugs. effective plasma conc. 600 mg of base stat 300 mg base after 8 hours 150 mg of base BD for 2 days 200 mg oral tablet of chloroquine phosphate consists of 150 mg base. erythrocytic schizonticide related to mefloquine MOA- similar to chloroquine -also affects nucleic acid and protein synthesis of parasite Fatty. Sigma-Aldrich offers a number of Chloroquine phosphate products. View information & documentation regarding Chloroquine phosphate, including CAS, MSDS & more.