Hydroxychloroquine-mediated retinopathy

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  1. iweblink Well-Known Member

    Hydroxychloroquine-mediated retinopathy


    Ophthalmic surveillance was performed on patients in a multicenter clinical trial testing high-dose (1000 mg daily) hydroxychloroquine for advanced non–small cell lung cancer. The US Food & Drug Administration–recommended screening protocol included only visual acuity testing, dilated fundus examination, Amsler grid testing, and color vision testing.

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    Hydroxychloroquine is a front-line treatment for systemic lupus erythematosus and other rheumatic diseases, but can cause retinopathy. Improved detection techniques for the early stages pre. Acute zonal occult outer retinopathy AZOOR is a retinal disease first described by Gass in 1992; reporting on 13 cases that shared the following features rapid loss of one or more large zones of outer retinal function, minimal fundus changes, electroretinographic abnormalities, and permanent visual field loss that was associated with delayed development of visible atrophic changes in the. Megan B. Goodman, Ari Ziskind, Fundus auto fluorescence and spectral domain ocular coherence tomography in the early detection of chloroquine retinopathy, African Vision and Eye Health, 2015, 74, 1CrossRef; 19 Junyeop Lee, Joo Yong Lee, Hydroxychloroquine Retinopathy, Journal of Rheumatic Diseases, 2015, 22, 3, 140CrossRef

    Out of the 7 patients having exposure of at least 6 months, 2 developed retinal toxicity (at 11 and 17 months of exposure). In patients seen at Stanford, additional sensitive screening procedures were added at the discretion of the retinal physician: high-resolution spectral-domain optical coherence tomography (OCT), fundus autofluorescence (FAF) imaging, Humphrey visual field (HVF) testing, and multifocal electroretinography (mf ERG).

    Hydroxychloroquine-mediated retinopathy

    Hydroxychloroquine DermNet NZ, Acute Zonal Occult Outer Retinopathy AZOOR - EyeWiki

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  4. Mar 27, 2007 In patients with systemic lupus erythematosus SLE, hydroxychloroquine prevents disease flares and damage accrual and facilitates the response to mycophenolate mofetil in those with renal involvement. A study was undertaken to determine whether hydroxychloroquine also exerts a protective effect on survival.

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    Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. Genetic Variants in Egyptian Patients Receiving HCQHydroxychloroquine HCQ The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U. S. Federal Government. Abstract. The 4-aminoquinolines are weak bases that are completely absorbed from the gastrointestinal tract, sequestered in peripheral tissues, metabolized in the liver to pharmacologically active by-products, and excreted via the kidneys and the feces.

     
  5. NellZam Guest

    Hydroxychloroquine (Plaquenil) is considered a disease-modifying anti-rheumatic drug (DMARD). Immune & Autoimmune - Lupus Plaquenil - when to take the. Hydroxychloroquine Plaquenil Success, Reviews and Side Effects Best time to take plaquenil - HealthBoards
     
  6. Endoff New Member

    Take this medicine exactly as directed by your doctor. Malaria Medications Common Malaria Pills Used to Treat. Chloroquine - Wikipedia Chloroquine Indications, Side Effects, Warnings -
     
  7. s-saint Moderator

    Hydroxychloroquine - Wikipedia Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine -sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda.

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