Despite drastic containment measures, the spread of this virus is ongoing. SARS-Co V-2 is the aetiological agent of coronavirus disease 2019 (COVID-19) characterised by pulmonary infection in humans. Medicine for lupus plaquenil Plaquenil charting Half life of plaquenil Availability. Hydrochloride 250 mg, 500 mg tablets; 5 mg, 50 mg/mL ampule Phosphate 250 mg, 500 mg tablets Actions. Antimalarial activity is believed to be based on its ability to form complexes with DNA of parasite, thereby inhibiting replication and transcription to RNA and nucleic acid synthesis. A 'read' is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the full-text. The nucleotide metabolism page discusses the biosynthesis and degradation of the nucleic acids as well as descriptions of diseases caused by defects in their metabolism. In the absence of a known efficient therapy and because of the situation of a public-health emergency, it made sense to investigate the possible effect of chloroquine/hydroxychloroquine against SARS-Co V-2 since this molecule was previously described as a potent inhibitor of most coronaviruses, including SARS-Co V-1. The efforts of international health authorities have since focused on rapid diagnosis and isolation of patients as well as the search for therapies able to counter the most severe effects of the disease. Chloroquine interfere nucleic acid biosynthesis Chloroquine - My Cancer Genome, Antimetabolites That Interfere with Nucleic Acid Biosynthesis. Plaquenil treatment for sarcoidosis Nucleic Acid Synthesis Nucleic acids are synthesized from triphosphate nucleotide precursors by DNA or RNA polymerases using DNA as a monophosphorylated nucleotides are linked together by phosphodiester bonds between the 3′ hydroxyl of ribose or deoxyribose, and the 5′ hydroxyl group of the next sugar in a 5′ to 3′ direction Fig. 14. Nucleic Acid Synthesis - an overview ScienceDirect Topics. Nucleotide Metabolism Nucleic Acid Synthesis and Catabolism. Biosynthesis of Nucleic Acids authorSTREAM. Inhibitors of Nucleic Acid Synthesis. Some antibacterial drugs work by inhibiting nucleic acid synthesis Table 5. For example, metronidazole is a semisynthetic member of the nitroimidazole family that is also an antiprotozoan. It interferes with DNA replication in target cells. Chloroquine is the prototype anti malarial drug, most widely used to treat all types of malaria except for disease caused by chloroquine resistant Plasmodium falciparum. It may also interfere with the biosynthesis of nucleic acids. This agent may also interfere with the biosynthesis of nucleic acids. Chloroquine's potential chemosensitizing and radiosensitizing activities in cancer may be related to its inhibition of autophagy, a cellular mechanism involving lysosomal degradation that minimizes the production of reactive oxygen species ROS related to tumor reoxygenation and tumor exposure to chemotherapeutic agents and radiation.