What is the mechanism of action of chloroquine and primaquine

Discussion in 'Chloroquine Online' started by Denst, 25-Feb-2020.

  1. etraff.com Guest

    What is the mechanism of action of chloroquine and primaquine


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Malaria is a protozoan infection, caused by the bite of the female Anopheles mosquito. This article reviews the various antimalarial drugs, mechanisms of action, adverse effects/toxicity, and drugs of choice. Important therapeutic aspects of individual drugs will also be covered. Mechanism of action Primaquine is lethal to P. vivax and P. ovale in the liver stage, and also to P. vivax in the blood stage through its ability to do oxidative damage to the cell. However, the exact mechanism of action is not fully understood. Mechanism of action Quinine is theorized to be toxic to the malarial pathogen, Plasmodium falciparum, by interfering with the parasite's ability to dissolve and metabolize hemoglobin. 32 As with other quinoline antimalarial drugs, the mechanism of action of quinine has not been fully resolved.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    What is the mechanism of action of chloroquine and primaquine

    Pathway-specific inhibition of primaquine metabolism by chloroquine/quinine, Primaquine - Wikipedia

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  4. Malaria caused by P. vivax or P. ovale is treated with chloroquine in Brazil at a dose of 30 mg/kg divided into three days and primaquine in the 30 mg dose/day for 7 days or 15 mg/day for 14 days. Also, low doses of chloroquine can be used for the prevention of vivax malaria.

    • Side Effects of Chloroquine and Primaquine and Symptom Reduction in..
    • Quinine - Wikipedia.
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    Chloroquine binds to heme or FP to form the FP-chloroquine complex; this complex is highly toxic to the cell and disrupts membrane function. Action of the toxic FP-chloroquine and FP results in cell lysis and ultimately parasite cell autodigestion. In essence, the parasite cell drowns in its own metabolic products. The exact mechanism by which chloroquine inhibits hemozoin formation is not known, but chloroquine can bind heme and this binding may prevent the heme from being incorporated into the hemozin crystal. Parasite killing is therefore a result of the accumulation of metabolic wastes ie, heme associated with the digestion of hemoglobin. Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which chloroquine exhibits activity is not known. Chloroquine, may exert its effect.

     
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