Her rheumatologist instructed her to undergo a baseline ocular examination prior to initiating Plaquenil (hydroxychloroquine, Sanofi-Aventis) therapy. Toxic maculopathy associated with chloroquine use was first documented in the literature five decades ago.1 In the United States, Plaquenil––an analog to chloroquine––is used to treat a variety of conditions, including rheumatoid arthritis, lupus and several distinct inflammatory disorders. Although the incidence of macular toxicity is infrequent with Plaquenil use (at a dosage of 200mg or 400mg q.d.), its visual impact can be devastating. Is 200 milligrams of hydroxychloroquine high Hydroxychloroquine generic Hydroxychloroquine sulfate is a colorless crystalline solid, soluble in water to at least 20 percent; chemically the drug is 2-4-7-Chloro-4-quinolylaminopentylethylamino ethanol sulfate 11. PLAQUENIL hydroxychloroquine sulfate tablets contain 200 mg hydroxychloroquine sulfate, equivalent to 155 mg base, and are for oral administration. These may occur for the first few days a person takes the drug while the body adjusts to the medication. Loss of appetite, tiredness, weakness, or headache are uncommon side effects and typically go away over time. Rare complications. The greatest concern people have when taking hydroxychloroquine is related to vision. Hydroxychloroquine Plaquenil and chloroquine cause ocular toxicity to various parts of the eye such as the cornea, ciliary body, and retina. Chloroquine can also induce cataract formation; however, no reports of hydroxychloroquine and cataract have been reported. This article focuses upon hydroxychloroquine retinopathy. Disease Initially, central visual acuity may be unaffected, but the patient may notice related paracentral scotomas that often interfere with reading. The associated classic retinal toxicity is described as a bull’s eye maculopathy (ring of depigmented retinal pigment epithelium that spares the foveal area). What must be evaluated while on hydroxychloroquine Hydroxychloroquine, anti-malarial drug, tapped for., Drug spotlight on hydroxychloroquine Lupus Foundation of. Hydroxychloroquine in lupus pregnancy.Is plaquenil a diureticHydroxychloroquine regular blood testWho should not take plaquenil Hydroxychloroquine is still a safe and beneficial drug for use in rheumatic diseases. Retinal toxicity is unpredictable and can occur even at relatively low doses of hydroxychloroquine. There are new screening modalities for early detection of asymptomatic hydroxychloroquine ocular toxicity. Hydroxychloroquine-related retinal toxicity Rheumatology.. Hydroxychloroquine toxicity - EyeWiki. Hydroxychloroquine for Sjögren Syndrome Symptoms - JAMA. Once the intravenous infusion of amphotericin B has begun, vital signs must be monitored frequently to assess for adverse reactions such as cardiac dysrhythmias, visual disturbances, paresthesias numbness or tingling of the hands or feet, respiratory difficulty, pain, fever, chills, and nausea. Abstract. Background The American Academy of Ophthalmology recommendations on screening for chloroquine CQ and hydroxychloroquine HCQ retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. Provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.