The patient had been on Amiodarone therapy for several years. These deposits occur in various levels of the cornea. Two months prior to this routine follow up, the patient's primary care doctor made a change in the patient's cardiac medications which included the removal of amiodarone from his medication regimen. Corneal verticillata, also called vortex keratopathy, are one type of corneal deposits. Celebrex and plaquenil What is hydroxychloroquine 400 mg used for Chloroquine for malaria in pregnancy Cornea verticillata also called vortex keratopathy, whorl keratopathy, or Fleischer vortex describes a whorl-like pattern of golden brown or gray opacities in the cornea. It is termed cornea verticillata from the Latin noun “verticillus,” meaning “whorl”. The cornea may become affected relatively commonly by an innocuous vortex keratopathy and is characterized by whorl-like corneal epithelial deposits. These changes bear no relationship to dosage and are usually reversible on cessation of hydroxychloroquine. Like a number of other drugs, HCQ and CQ can cause corneal verticillata also known as vortex keratopathy. These epithelial changes arise due to precipitation of the drug, typically forming a whorl-like pattern that is reversible with drug cessation 7. The opacities branch out from a central whorl, usually across the inferior cornea. Verticillata are readily recognizable by their distinct appearance as fine, golden-brown or gray opacities that are almost always bilateral. Vortex keratopathy hydroxychloroquine Ocular Side effects of Oral Medications Flashcards Quizlet, PLAQUENIL hydroxychloroquine and the Eye Westford Dosage for plaquenil Toxicity from hydroxychloroquine may be seen in two distinct areas of the eye, the cornea, and the macula. The cornea may become affected relatively commonly by an innocuous vortex keratopathy characterized by whorl-like corneal epithelial deposits. Hydroxchloroquine and Chloroquine Toxicity - Eye Lessons. Hydroxychloroquine-related retinal toxicity Rheumatology.. Early Plaquenil Toxicity Detected without Bull’s Eye Maculopathy. Other signs are Pancreatitis, Lupus Enteropathy, Hepatitis and Hepatomegaly 5. Systemic Fever, Malaise/Fatigue, Lymphadenopathy, Weight loss 6.fidanoski.ca The long-term administration of hydroxychloroquine HCQ sulfate is well known to be associated with AE, such as vortex keratopathy and in particular the often irreversiblenih.gov keratopathy and maculopathy. Corneal deposits called vortex keratopathy or corneal verticillata result from binding to cellular lipids and deposition of the drug in the basal epithelial layer of the cornea. Discontinuation of the drug usually causes the deposits to disappear over time. Toxicity from hydroxychloroquine may be seen in two distinct areas of the eye the cornea and the macula. The cornea may become affected relatively commonly by an innocuous cornea verticillata or vortex keratopathy and is characterized by whorl-like corneal epithelial deposits. These changes bear no relationship to dosage and are usually reversible on cessation of hydroxychloroquine.