We aimed to compare the efficacy and safety of HCQ and corticosteroid treatment in patients with Ig AN. Ninety-two patients with Ig AN who received HCQ in addition to routine renin-angiotensin-aldosterone system inhibitors (RAASi) therapy were included. Ninety-two matched historical controls who received corticosteroids were selected by propensity score matching. Baseline proteinuria levels were comparable between the HCQ and corticosteroid groups (1.7 [1.2, 2.3] vs. The percentage reduction in proteinuria at 6 months was smaller in the HCQ group than in the corticosteroid group (− 48.5% [− 62.6, − 31.4] vs. The time averaged proteinuria within the 6 months of observation was comparable for the HCQ and corticosteroid groups (1.1 [0.8, 1.5] vs. The cumulative frequency of patients with a 50% reduction in proteinuria during the study was also comparable between the two groups (52.2% vs. However, six of the 92 (6.5%) patients suffered from severe adverse events (SAEs) in the corticosteroid group, while no SAEs were observed in the HCQ group (6.5% vs. The antiproteinuric effect of HCQ might be slightly inferior to that of corticosteroids over 6 months in patients with Ig AN who were deemed to be candidates for HCQ and not corticosteroids treatment. Hydroxychloroquine radiotherapy Ingredients hydroxychloroquine Hydroxychloroquine Plaquenil® is a 4-amino-quinoline antimalarial medication that is widely used to treat systemic lupus erythematosus SLE, rheumatoid arthritis, and related inflammatory and dermatological conditions. It is a hydroxylated version of chloroquine, with a similar mechanism of action. Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil is available in generic form. While side effects of corticosteroids are usually to blame, there is also the possibility of ocular damage associated with long-term use of the antimalarial drugs hydroxychloroquine brand name Plaquenil® and chloroquine. Improved vision screening tests and updated dosing guidelines are key to avoiding such complications. Ig A nephropathy (Ig AN) is the most prevalent type of primary glomerulonephritis worldwide . However, HCQ treatment was safer than corticosteroid treatment. Corticosteroids vs plaquenil Plaquenil vs Prednisone Comparison -, Plaquenil vs. Rheumatrex, Trexall Prescription Treatment for Rheumatoid. Plaquenil and diabetesWhat is the difference between methotrexate and plaquenilWhat percent of people on plaquenil have eye problemsHow can you get hydroxychloroquine retinopathyPlaquenil cyst buster Yes, anti-malarials can be taken with other lupus medications, including corticosteroids e.g. prednisone, immunosuppressives, cytotoxic drugs, and NSAIDs. Anti-malarial drugs may be given in combination with prednisone to reduce the amount of steroid needed to control lupus symptoms and thus to alleviate some of the side effects of the steroid. Treating Lupus with Anti-Malarial Drugs Johns Hopkins.. Protecting your eyesight when taking Plaquenil Lupus Foundation of.. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. Corticosteroids are medications often used to treat arthritis and related conditions. These medications are widely used because of their overall effectiveness in reducing inflammation--the process that causes the joint pain warmth and swelling of arthritis and related conditions. Lbs or less - up to 200 mg Plaquenil daily; A lupus patient explains her changes in vision. Ann Utterback, 67, a broadcast voice specialist who lives in Gaithersburg, Md. was diagnosed with lupus in 2005. She says she’s always been extra-sensitive to medications, and her vision loss is related to both corticosteroids and Plaquenil. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria.