Chloroquine elimination route

Discussion in 'Certified Online Canada Pharmacy' started by OlegB, 19-Mar-2020.

  1. cls-group Guest

    Chloroquine elimination route


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    AUCs, calculated for the time period of 0 to 168 hr were proportional to the doses. Mean AUC value increased 6.7 times when the dose was increased 7.5 times from 2 to 15 mg/kg. These data do not support the existence of significant capacity‐limited chloroquine elimination within the dose range studied. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. Occasionally it is used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus. Subsequent treatment starting on June 30 with a higher dose of chloroquine first day 600 mg, second day 600 mg, third day 300 mg, and primaquine 7-5 mg 3 times a day for 14 days resulted in the clearance of parasites but fever and parasitaemia 5100/ul recurred on August 12.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine elimination route

    Pharmacokinetics of Quinine, Chloroquine and Amodiaquine., Chloroquine - Wikipedia

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  6. Anti-malarial resistance is, and continues to be a significant challenge in the fight against malaria and a threat to achieving malaria elimination. In Zambia, chloroquine CQ, a safe, affordable and well-tolerated drug, was removed from use in 2003 due to high levels of resistance evidenced with treatment failure.

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    Dec 03, 2019 BACKGROUND Anti-malarial resistance is, and continues to be a significant challenge in the fight against malaria and a threat to achieving malaria elimination. In Zambia, chloroquine CQ, a safe, affordable and well-tolerated drug, was removed from use in 2003 due to high levels of resistance evidenced with treatment failure. Chloroquine is detectable in the urine for up to a year after drug administration. 94 Urinary excretion is the main route of elimination for both chloroquine and desethylchloroquine. The risk may also be higher with some doses of chloroquine, if you use chloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen. Call your doctor right away if you have any eyesight changes like blurred or foggy eyesight, trouble focusing or reading, or trouble seeing in dim light.

     
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