Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil and coffee Macular degeneration from plaquenil Using pei vs chloroquine transfection Malaria drug hydroxychloroquine Can Plaquenil cause Neutropenia? Neutropenia is a known side effect of Plaquenil. Complete analysis from patient reviews and trusted online health resources, including first-hand experiences. Many diseases can cause extreme fatigue and weakness. Anemia can cause extreme fatigue and weakness. The Mayo Clinic website reports that anemia occurs when a person lacks sufficient red blood cells or iron to carry oxygen to her tissues and organs and that a person with anemia will experience weakness and fatigue. While pernicious anemia is defined as anemia resulting from inadequate absorption of vitamin B-12 from the gastrointestinal tract due to the autoimmune process described above, other causes of vitamin B-12 deficiency can also produce the characteristic signs and symptoms of pernicious anemia. Other potential causes of vitamin B-12 deficiency. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Can plaquenil cause anemia Macrocytosis What causes it? - Mayo Clinic, Diseases Causing Extreme Fatigue & Weakness Healthfully Optomolologist plaquenil eye exam montgomery al Summary. Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. Hydroxychloroquine Plaquenil Side Effects & Dosage for.. Pernicious Anemia Vitamin B-12 Deficiency Symptoms and Signs Causes. Rheumatoid Arthritis and Anemia Are They Connected?. Serious side effects are rare. The most common side effects are nausea and diarrhea, which often improve with time. Less common side effects include rash, changes in skin pigment such as darkening or dark spots, hair changes, and muscle weakness. Rarely, hydroxychloroquine can lead to anemia in some individuals. Plaquenil and Aplastic anemia - a study from real-world data. Summary Aplastic anemia is found among people who take Plaquenil, especially for people who are female, 30-39 old, have been taking the drug for 6 - 12 months, also take medication Prednisone, and have Paroxysmal nocturnal haemoglobinuria. Acquired autoimmune hemolytic anemia, or AIHA, is a rare type of you have anemia, your bone marrow doesn't make enough red blood cells. Or, these cells don't work as well as they should.