Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. How to stop hydroxychloroquine Hydroxychloroquine pregnancy lupus Aug 14, 2013 Hydroxychloroquine is an antimalarial medication that can cause hyperpigmentation of nails, mucosa, and skin 1–5. Retrospective studies cite the incidence of drug-related hyperpigmentation from hydroxychloroquine to be as high as 33% of individuals. Elder abuse is a cause of significant morbidity and mortality in older individuals 7–9. The risk of hydroxychloroquine-related retinopathy associated with skin hyperpigmentation is unknown.3 The risk of eye toxicity increases sharply toward 1% after five to seven years of hydroxychloroquine use, or a cumulative dose of 1000 g.4 Skin rashes and pigment change. Atabrine, specifically, can cause yellow pigmentation of skin. Sometimes Plaquenil can also deposit in the tissues of the body and cause the skin to take on a greenish tone. Dry skin Loss of appetite Abdominal bloating Upset stomach Stomach cramps Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Hydroxychloroquine yellow skin Hydroxychloroquine Oral Route Side Effects - Mayo Clinic, Hydroxychloroquine-related skin discoloration CMAJ Plaquenil online greecePlaquenil and ldn Hydroxychloroquine-induced pigmentation lesions usually begin after a few months or years of treatment. When we compared our patients with the controls, we found no significant association with the duration of HCQ treatment or with the cumulative dose of HCQ. Hydroxychloroquine-Induced Pigmentation in Patients With.. Plaquenil and spots on skin DailyStrength. Hydroxychloroquine Skin Support. Tell your doctor if you have or have ever had liver disease, psoriasis, porphyria or other blood disorders, G-6-PD deficiency, dermatitis skin inflammations, or if you drink large amounts of alcohol. tell your doctor if you have ever had vision changes while taking hydroxychloroquine, chloroquine Aralen, or primaquine. Skin Hyperpigmentation with Hydroxychloroquine Hydroxychloroquine Plaquenil is a common trade name is an anti-inflammatory oral medication that is commonly used to treat many autoimmune diseases. In the hair clinic, we use it for diseases such as lichen planopilaris, frontal fibrosing alopecia, Plaquenil or hydroxychloroquine has been known to cause a darkened discoloration of skin and/or mucous membranes. This is considered an adverse reaction and should be discussed with your prescriber. It is important to evaluate this color change to make sure there is nothing else wrong.