Chloroquine endosome

Discussion in 'Canadian Pharmacy Online' started by granatacchostbiz, 29-Feb-2020.

  1. Giniro Moderator

    Chloroquine endosome


    -Suppressive therapy should continue for 8 weeks after leaving the endemic area. Approved indication: For the suppressive treatment of malaria due to Plasmodium vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: 300 mg base (500 mg salt) orally once a week Comments: -For prophylaxis only in areas with chloroquine-sensitive malaria -Prophylaxis should start 1 to 2 weeks before travel to malarious areas; should continue weekly (same day each week) while in malarious areas and for 4 weeks after leaving such areas.

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    Unfortunately, Chloroquine, as well as other endosomal escape or endolytic agents, are often too toxic for use in preclinical models or eventual clinical trials of macromolecular therapeutics. Chloroquine is a weak base that can rapidly penetrate the plasma membrane, accumulate in acidic vesicles and increase the pH of the acidic compartment Maxfield 1982; Mellman, Fuchs et al. 1986. Preventing endosome acidification may subsequently inhibit hydrolytic enzymes such as proteases and nucleases Cotten, Längle-Rouault et al. 1990. The importance of preventing the degradation of therapeutics in the endosomes/lysosomes has been exemplified by the use of lysosomotrophic agents such as chloroquine which prevents the activity of lysosomal enzymes. In this review, several mechanisms which have been proposed for endosomal escape as well as the agents which are known to have.

    Approved indication: For acute attacks of malaria due to P vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: Chloroquine-sensitive uncomplicated malaria (Plasmodium species or species not identified): 600 mg base (1 g salt) orally at once, followed by 300 mg base (500 mg salt) orally at 6, 24, and 48 hours Total dose: 1.5 g base (2.5 g salt) Comments: -For the treatment of uncomplicated malaria due to chloroquine-sensitive P vivax or P ovale, concomitant treatment with primaquine phosphate is recommended. 60 kg or more: 1 g chloroquine phosphate (600 mg base) orally as an initial dose, followed by 500 mg chloroquine phosphate (300 mg base) orally after 6 to 8 hours, then 500 mg chloroquine phosphate (300 mg base) orally once a day on the next 2 consecutive days Total dose: 2.5 g chloroquine phosphate (1.5 g base) in 3 days Less than 60 kg: First dose: 16.7 mg chloroquine phosphate/kg (10 mg base/kg) orally Second dose (6 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Third dose (24 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Fourth dose (36 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Total dose: 41.7 mg chloroquine phosphate/kg (25 mg base/kg) in 3 days Comments: -Concomitant therapy with an 8-aminoquinoline compound is necessary for radical cure of malaria due to P vivax and P malariae.

    Chloroquine endosome

    Inhibition of Endosomal/Lysosomal Degradation Increases the Infectivity., Endosomal Escape Pathways for Non-Viral Nucleic Acid Delivery Systems.

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  6. Chloroquine 、中 氯喹 は抗マラリア剤のひとつ。マラリアの治療もしくは予防のために用いられる。1934年にドイツで最初に合成された。 現在ではクロロキンに耐性を持つマラリア原虫が出現している。そのためクロロキン単独で用いることは.

    • Wikipedia.
    • Endosomal escape pathways for delivery of biologicals..
    • Targeting endosomal acidification by chloroquine analogs as a..

    To examine the consequences of UPS buffering of luminal pH on endosome protein coat maturation, UPS 6.2 and UPS 4.4 were selected to study the recruitment of the Rab5 GTPase, which is a discriminating feature of early endosome pH 6.0–6.5 biogenesis, and LAMP2, which is a biomarker of lysosomes pH 4.0–4.5. Fluorescent dextran was used. Mar 11, 2002 Chloroquine is one of the drugs commonly used to treat malaria in parts of sub-Saharan Africa, where HIV infection is endemic 3, 27, 31, 47. Our initial observation that chloroquine increased the infectivity of HIV suggested that administration of chloroquine to HIV-infected patients could potentially exacerbate the course of HIV infection. Chloroquine is a lysosomotropic agent that prevents endosomal acidification 1. It accumulates inside the acidic parts of the cell, including endosomes and lysosomes. This accumulation leads to inhibition of lysosomal enzymes that require an acidic pH, and prevents fusion of endosomes and lysosomes.

     
  7. Profrukt Moderator

    Applies to hydroxychloroquine: oral tablet Along with its needed effects, hydroxychloroquine may cause some unwanted effects. Chloroquine - LiverTox - NCBI Bookshelf Side Effects of Chloroquine and Primaquine and Symptom. Chloroquine Aralen - Side Effects, Dosage, Interactions - Drugs
     
  8. ontolaGof Well-Known Member

    The page you are trying to reach is not available on our site. The page name may have changed, you may have happened upon a broken link, or the URL may be entered incorrectly. Plaquenil Hydroxychloroquine - Side Effects, Dosage. Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria Hydroxychloroquine Oral Route Proper Use - Mayo Clinic
     
  9. Torch! User

    Plaquenil when allergic to sulfa? Lupus Forums at The Lupus. Feb 17, 2009 Plaquenil isn't a 'sulfa' drug which means a certain sort of antibiotic, the sulfonamides. Plenty of people who are allergic to those sulfa drugs take Plaquenil without any problem. This sounds all very odd to me!

    Is hydroxychloroquine Sulfate a member of the sulfa drug.