Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Chloroquine pigmentation Desethyl hydroxychloroquine Plaquenil prevent lupus Chloroquine is a prescription Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. Swelling, increased mobility does not occur within six months, the drug should be discontinued. Safe use of the drug in the treatment of juvenile arthritis has not been established. Precautions Dermatologic reactions to PLAQUENIL may occur and, therefore, proper care should be Hydroxychloroquine is in a class of drugs called antimalarials. It is used to prevent and treat acute attacks of malaria. It is also used to treat discoid or systemic lupus erythematosus and rheumatoid arthritis in patients whose symptoms have not improved with other treatments. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil safe dosage Drug spotlight on hydroxychloroquine Lupus Foundation of., PLAQUENIL® - Food and Drug Administration Does hydroxychloroquine cause human birth defectsHydroxychloroquine and back painLow body fat and increase risk for chloroquine toxicityPlaquenil and allergy testing Wrong Hydroxychloroquine Dose Is Common, Putting Eyes at Risk Up to half of patients treated with the arthritis drug hydroxychloroquine Plaquenil are prescribed more than the recommended maximum amount, according to new research. Wrong Hydroxychloroquine Dose Is Common, Putting Eyes at Risk - News. Hydroxychloroquine MedlinePlus Drug Information. Plaquenil toxicity and lowering dosage What You Sjo. Abstract. Background The American Academy of Ophthalmology recommendations on screening for chloroquine CQ and hydroxychloroquine HCQ retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. Hydroxychloroquine may inhibit P-glycoprotein P-gp. Digoxin is a substrate for P-gp transport. For patients on a stable digoxin regimen and initiating hydroxychloroquine, no initial dose adjustment of either drug has been advised; however, serum digoxin concentrations should be monitored and used for digoxin dose titration as clinically. People taking 400 mg of hydroxychloroquine or less per day generally have a negligible risk of macular toxicity, whereas the risk begins to go up when a person takes the medication over 5 years or has a cumulative dose of more than 1000 grams. The daily safe maximum dose for eye toxicity can be computed from one's height and weight using this.