The doctor said that given where I am right now (constant low level pain and light swelling of my hands and wrists but no joint damage showing up on xrays or the ultrasound), she gave me a choice of starting on either Plaquenil or Methotrexate. She went over some info on each drug and then gave me some time to think about which would be better for me. My largest concerns center around the side effects of each... Plaquenil use for sjogrens syndrome Plaquenil for uti Arthritis medicine hydroxychloroquine Methotrexate is once a week usually and most of the side effects would hit the next day so some people choose to take it on a Friday or Saturday night and sleep through any potential side effects some people report that caffeine may lower the efficacy of methotrexate, though results have been inconclusive. We aimed to compare the efficacy of methotrexate and hydroxychloroquine on refractory lichen planopilaris. Methods In a randomized clinical trial, 29 patients were randomly allocated to receive either 15 mg methotrexate/week or 200 mg hydroxychloroquine twice a day for 6 months. View side-by-side comparisons of medication uses, ratings, cost, side effects, interactions and more. Hydroxychloroquine Remove Hydroxychloroquine from your drug comparison Methotrexate Remove Methotrexate from your drug comparison Celebrex celecoxib Remove Celebrex from your drug comparison Add to compare I also want to be sure that I'm taking a drug that will slow/stop the progression of the disease. With Plaquenil, the possibility of permanent vision damage scares me. Methotrexate vs hydroxychloroquine Methotrexate vs Plaquenil Comparison -, Clinical efficacy and safety of methotrexate versus hydroxychloroquine. Hydroxychloroquine poisoning Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. Otrexup methotrexate is the first-choice treatment for many types of cancer and arthritis, but it has many side effects. Compare Plaquenil vs Methotrexate -. Hydroxychloroquine Compared to Alternatives -. Combination therapy with methotrexate and.. Plaquenil is one of the firs line drugs and may or may not have side effects. MTX is more of a "chemo" medication and may or may not have side effects. I would encourage you to look at quality of life issues and go slowly if you are not in a hurry to squelch all of the discomfort of RA. Sorry to hear that you are having a lot of pain with your RA. I have lupus which mainly affects my joints and skin. I have been taking hydroxychloroquine which is the generic of plaquenil for the past three years. My rheumy recently added Imuran instead of methotrexate. Plaquenil hydroxychloroquine takes up to 3 months to begin working. Hello hope everyone is well just a quick question, i have been on methotrexate for 2 months increasing from 7.5 to 15 and now to 25mg.weekly now been given plaquenil 400mg daily, has anyone else been on this mixture and has it worked or how long should i wait to see if it works.