I don't get many side effects generally, but with prednisone I DO. It does help, but this can't be a long term affair. Plaquenil is a great drug (I have no experience with it, but many people with lupus take it). I'd ask your rheumy about it and have them explain why they made that choice for you. Prednisone is an intermediate acting corticosteroid-which means it has direct anti-inflamitory properties that take effect begining in a few hours. Is plaquenil another option instead of the prednisone? It is ment to get this undercontrol now and diminish your pain. Hydroxychloroquine-mediated retinopathy Chloroquine phosphate suspension ip Plaquenil and leukemia Chloroquine retinopathy guidelines Do not abruptly stop taking steroids. You should not stop taking steroids abruptly if you have been taking them for more than 4 weeks. Once your body has adjusted to taking steroids, your adrenal glands may shrink and produce less natural cortisone. There are guidelines on the amount of Plaquenil a person should be able to take safely in a lifetime, and Katz encourages those taking the medication to discuss this with their ophthalmologists. “I think there are some people, like Ann, whose bodies, for whatever reason, don’t metabolize drugs as well,” he says. You and your doctor should decide whether you’ll take this medication or breastfeed. For seniors This drug is processed by your kidneys. Older adults with reduced kidney function may not be. It has not direct anti-inflamitory properties and instead works on the immune system-though the mechanism is not known. Plaq is a longer time medication it may take two months before their is a noticable difference. Should you take plaquenil with steroids Benefits and Risks of Prednisone, Protecting your eyesight when taking Plaquenil Lupus. Plaquenil 200 mg en español They wanted me to go on steroids, but I have a really bad reaction with them, so now I don't know if there is anything I can be given to control my MCTD. Does anyone know if there is any other treatments or meds that have worked for you if you can't take Plaquenil or steroids? If you can't take Plaquenil DailyStrength. Hydroxychloroquine Side Effects, Dosage, Uses, and More. Danger in taking Plaquenil and Prednisone if its not Lupus.. Compare Plaquenil vs. Prednisone, which is better for uses like Lupus, RA and Sjogren's Syndrome. Compare head-to-head ratings, side effects, warnings, dosages, interactions and patient reviews. Patients rated Plaquenil 3.7/5 over Prednisone 3.2/5 in overall satisfaction. Side effects of Plaquenil and prednisone that are similar include nausea, vomiting, or headache. Side effects of Plaquenil that are different from prednisone include stomach pain or cramps, loss of appetite, weight loss, diarrhea, dizziness, spinning sensation, ringing in your ears, mood changes, nervousness, irritability, skin rash, itching, or hair loss. I didn’t stay on Plaquenil for long tho since it had an almost immediate reaction to my eyes. I know this is a side effect for some people and you should be regularly seeing an opthamologist while you are on Plaquenil I’m not a dr, but I do know that it is usually brought to your attention when they put you on this particular medicine.