Synthesis of chloroquine phosphate

Discussion in 'Canadian Pharcharmy' started by miok, 21-Feb-2020.

  1. lotar XenForo Moderator

    Synthesis of chloroquine phosphate


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Majority of these viruses are responsible for the outbreaks of pathogenic lethal infections. To date, there are no effective therapeutic strategies available for the prophylaxis and treatment of these infections. Chloroquine analogs have been used for decades as the primary and most successful drugs against malaria. That would be the synthesis of chloroquine from 4,7-dichloroquinoline and 4-diethylamino-1-methylbutylamine, where both starting materials are available through well-known procedures. share improve this answer Chloroquine Phosphate. Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Synthesis of chloroquine phosphate

    Design and Synthesis of Novel Chloroquine-based Antimalarials, Synthesis of chloroquine from 4-amino-7-chloroquinoline - Stack Exchange

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    • Synthesis of Chloroquine vitoribecco2013's Blog.
    • Chloroquine Phosphate - WebMD.
    • General Preparation - Chloroquine Phosphate Injection..

    A New Synthesis of Chloroquine Chloroquine, introduced into medicine in the 1940s, is a member of an important series of chemically related antimalarial agents, the quinoline derivatives. Chloroquine is administered orally as chloroquine phosphate. It also can be given by intramuscular injection as chloroquine hydrochloride. Chloroquine is a 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite.

     
  6. Denny_A Moderator

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Chloroquine Aralen - Side Effects, Dosage, Interactions. Chloroquine Is a Zinc Ionophore - PubMed Central PMC Chemical Database Chloroquine
     
  7. WEBMONEY МОСКВА XenForo Moderator

    PowerPoint. Update on Plaquenil Testing Plaquenil is 200 mg BID. Is this too much? 2011 Guidelines warned about cumulative dose of 1000g or exceeding 6.5 mg/kg/day. For a typical patient, most will reach the cumulative dose at 2000 mg BID in five years.

    Hydroxychloroquine-induced retinal toxicity in systemic lupus.
     
  8. Nikitos Well-Known Member

    Plaquenil hydroxychloroquine sulfate dose, indications. Hydroxychloroquine may inhibit P-glycoprotein P-gp. Digoxin is a substrate for P-gp transport. For patients on a stable digoxin regimen and initiating hydroxychloroquine, no initial dose adjustment of either drug has been advised; however, serum digoxin concentrations should be monitored and used for digoxin dose titration as clinically.

    Plaquenil Hydroxychloroquine - Side Effects, Dosage.