Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. Plaquenil uses for lupus Plaquenil and borderline personality disorder An alternative to chloroquine for prophylaxis only in areas with chloroquine-sensitive malaria 310 mg base 400 mg salt orally, once/week 5 mg/kg base 6.5 mg/ kg salt orally, once/week, up to maximum adult dose of 310 mg base Begin 1–2 weeks before travel to malarious areas. Because of its record of safety and efficacy, chloroquine remains the primary prophylactic drug of choice for travelers to all malarious areas, including areas with CRPF. In all areas with CRPF, there is malaria caused by one or more other species of Plasmodium P. vivax, P. ovale, P. malariae that remain sensitive to chloroquine. Jun 15, 2003 A concerted national effort to withdraw chloroquine from use has been followed by a return of chloroquine-sensitive falciparum malaria in Malawi. The reintroduction of chloroquine, ideally in combination with another antimalarial drug, should be considered in areas where chloroquine resistance has declined and safe and affordable alternatives. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. It is recommended to check if chloroquine is still effective in the region prior to using it. Chloroquine sensitive malaria areas Malaria - Chapter 4 - 2020 Yellow Book Travelers' Health CDC, Revised Recommendations for Preventing Malaria in. Plaquenil generico These interactive maps, based on the WHO global antimalarial drug efficacy database, provide a visual overview of therapeutic efficacy study results, according to malaria species, antimalarial treatment, year and geographic location. WHO Antimalarial drug efficacy maps. Reemergence of Chloroquine-Sensitive Plasmodium falciparum.. CDC - Malaria - Malaria Worldwide - How Can Malaria Cases and.. Chloroquine CQ was the cornerstone of anti-malarial treatment in Africa for almost 50 years, but has been widely withdrawn due to the emergence and spread of resistance. Recent reports have suggested that CQ-susceptibility may return following the cessation of CQ usage. Here, we monitor CQ sensitivity and determine the prevalence of genetic polymorphisms in the CQ resistance transporter. Areas with chloroquine-sensitive malaria include many Latin American countries where there is predominantly P. vivax malaria. Chloroquine-sensitive P. falciparum is present in the Caribbean and Central American countries west of the Panama Canal. For destinations where chloroquine-sensitive malaria is present, in addition to mosquito avoidance measures, the many effective prophylaxis options include chloroquine, atovaquone-proguanil, doxycycline, mefloquine, and tafenoquine. Most parts of India have a high transmission of P. vivax malaria and chloroquine resistant P. falciparum is now reported from many parts of India. The high altitude states of Jammu and Kashmir, Himachal Pradesh and Sikkim are free from malaria. Malaria transmission is low or very low in areas at an altitude 2000 metres.