They can signal a condition called peripheral neuropathy, or nerve damage. Lupus is an autoimmune condition that causes the immune system to attack normal, healthy cells and tissue. What drug classification is plaquenil Glaucoma and plaquenil Plaquenil toxicity treatment Hydroxychloroquine for skin rash A small fiber neuropathy occurs when damage to the peripheral nerves predominantly or entirely affects the small myelinated Aδ fibers or unmyelinated C fibers. The specific fiber types involved in this process include both small somatic and autonomic fibers. The sensory functions of these fibers include thermal perception and nociception. The name “lupus” usually refers to the most common form, systemic lupus erythematosus. This disease is called systemic because it can affect many parts of the body. It is characterized by inflammation and damage to different tissues and organs with many symptoms including fatigue and fever, swollen or painfully inflamed joints, and skin rashes. Lupus may attack the nervous system via antibodies that bind to nerve cells or the blood vessels that feed them, or by interrupting the blood flow to nerves. Cognitive Dysfunction The most common manifestation of neuro-lupus is cognitive dysfunction, which is characterized by clouded thinking, confusion, and impaired memory. When several nerves in the body are affected it's referred to as polyneuropathy—the most common type of peripheral neuropathy. About 10 to 15 percent of people with lupus experience symptoms of peripheral neuropathy. Plaquenil nerve damage Plaquenil causes and treats neuropathy? - NeuroTalk Support., Systemic Lupus Erythematosus The Foundation For Peripheral. Plaquenil medication similarPlaquenil and eye damageFda approval chloroquine-primaquinePlaquenil skin sloughing Side effects include irritability, headache, weakness, hair lightening or loss, stomach upset, nausea, dizziness, muscle pain, rash and itching. Rarely, hydroxychloroquine can affect the bone marrow leading to reduced white blood cells leukopenia or platelets thrombocytopenia and abnormal red blood cells anemia. Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria. How Lupus Affects the Nervous System Johns Hopkins. Optic nerve vasculopathy and plaquenil - Autoimmune.. Do not take PLAQUENIL if you have retinopathy eye problem affecting the retina. PLAQUENIL may cause irreversible damage to the retina the back of the eye where vision is created. You are required to have an eye exam before taking PLAQUENIL, then a follow-up as often as needed while taking PLAQUENIL. As PLAQUENIL may enhance the effects of a hypoglycemic treatment, a decrease in doses of insulin or antidiabetic drugs may be required. Drugs That Prolong QT Interval And Other Arrhythmogenic Drugs. PLAQUENIL prolongs the QT interval and should not be administered with other drugs that have the potential to induce cardiac arrhythmias. Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. The New Zealand Dermatological Society recommends that to decrease the risk of retina damage, no more than 200mg of Plaquenil should be taken a day, and a dose of 400mg per day should be taken no longer than a few weeks.