Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil side effects fatigue Hydroxychloroquine cream side effects Plaquenil flu shot Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. Plaquenil hydroxychloroquine is an anti-malarial medication used to effectively treat rheumatoid arthritis and autoimmune conditions such as systemic lupus erythematosus and Sjögren’s Syndrome. Plaquenil is a drug that is stored in high concentrations throughout the body and is very slowly eliminated from the body. Plaquenil can change the pigmentation in the skin, so it would stand to reason that it can do the same with hair. I have experienced the change in pigmentation on my legs. It looks like I have a huge bruise on the back of my leg which extends from the calf to the ankle. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil cataracts Plaquenil Side Effects Common, Severe, Long Term -, PLAQUENIL hydroxychloroquine and the Eye Westford Granulomatous nodules treated with plaquenilHydroxychloroquine should you take if you are anemicDrugs.com hydroxychloroquine Sep 07, 2017 A cataract causes a gradual clouding of the eye lens, which may be corrected by cataract surgery. It’s also possible to develop cataracts on top of Fuchs’ dystrophy. If this happens, you may. Fuchs’ Dystrophy Treatments, Symptoms, and Stages. Plaquinel changes hair color?" Lupus Community - Support Group. Taking Plaquenil for Rheumatoid Arthritis. Her ophthalmologist detected a cataract in her right eye, caused by steroids, but he didn’t think it was causing the problem she was having. After cataract surgery she noticed a difference, but it was not what she was expecting. “After the surgery, the blind area was more noticeable because my sight in that eye was so much clearer,” she says. Plaquenil Toxicity with a bullseye pattern of central pigment loss. The risk of macular damage is dependent on the daily dose and duration of use, although kidney disease and tamoxifen increase this risk. At recommended doses, the risk of toxicity up to 5 years is under 1%, under 2% up to 10 years. Cataract is clouding of your natural lens which impairs light from reaching the back of the eye. It is a normal aging change but can be accelerated by certain drugs and medical disorders such as diabetes.