Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Sjogren's pregnancy heart block hydroxychloroquine Can i take a multivitamin with hydroxychloroquine Was the plaquenil controlling your RA symptoms? The trouble is you lose hair on Methotrexate too. But after losing heaps when I first went on it, I have stabalised now, I have thinner hair but it still looks fine and healthy. If plaq was working for your symptoms I'd go back on it. If you feel like the RA is escallating then go for mtx. Plaquenil is better than Sulfazalizine but the Arava is still more effective than the Plaq. Can't imagine Plaquenil by itself being very effective for moderate to severe. only good for mild cases. Keep in mind that Arava can really take a full three months to acheive full effectiveness. keep taking Plaq until then. Plaquenil vs Methotrexate. By Guest 1. meds. My RA has improved, I think, on the current regime of meds. Can you compare me Plaquenil and methotrexate, maybe methotrexate, would be better for me. Comparison of Plaquenil and methotrexate is difficult. Both drugs are very well tolerated and have different side effects, but if you have. Recently my eyes have felt sore and, after posting a question on this site, I am seeing my GP on Monday. Thanks Hi Catjones I have been taking this combination, started on both of them in January this year. Is plaquenil safer than methotrexate Which would you pick and why? - Plaquenil or Methotrexate, Anyone used plaquenil and arava which is better? DailyStrength How long does chloroquine itching lastCan plaquenil help fibromyalgiaChloroquine solubility in water Clinical practice guidelines recommend use of combination DMARDs such as hydroxychloroquine plus methotrexate for patients with a disease duration less than 6 months and moderate disease activity and poor prognostic features and is an option for high disease activity and poor prognostic features. Plaquenil hydroxychloroquine sulfate dose, indications.. Plaquenil vs Methotrexate Antineoplastics Cancer drugs.. Choosing Medications for Rheumatoid Arthritis - NCBI Bookshelf. Methotrexate is classified as a disease-modifying anti-rheumatic drug DMARD. The drug decreases pain and swelling associated with rheumatoid arthritis, slows progression of the disease, and helps prevent joint damage. When considering effectiveness and safety, is methotrexate injection better than oral methotrexate? Other than that I have had some GI issues when the Plaquenil was increased, but I seem to now be adjusting to it as well. Both have really helped as my inflammation markers are now back in the normal ranges in my blood work--they were 600 times normal before I began. I still have joint pain, but it is much less than before. Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. Otrexup methotrexate is the first-choice treatment for many types of cancer and arthritis, but it has many side effects.