Controlled studies in pregnant women show no evidence of fetal risk. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. Animal studies show risk and human studies not available or neither animal nor human studies done. Contact the applicable plan provider for the most current information. D: Use in LIFE-THREATENING emergencies when no safer drug available. Interaction between plaquenil and augmentin i Plaquenil dosage lyme Hydroxychloroquine for lichen planus Plaquenil causing lyme herxing A severe eye problem has happened with chloroquine. This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems. The risk may also be higher with some doses of chloroquine, if you use chloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen. For these reasons, and because chloroquine has not been found to have any harmful effects on the fetus when used in the recommended doses for malaria prophylaxis, pregnancy is not a contraindication to malaria prophylaxis with chloroquine or hydroxychloroquine. Chloroquine enters the red blood cell, inhibiting the parasite cell and digestive vacuole by simple diffusion. Chloroquine then becomes protonated to CQ2+, as the digestive vacuole is known to be acidic pH 4.7; chloroquine then cannot leave by diffusion. Active against erythrocytic forms of Plasmodium vivax & P. malariae and most strains of Plasmodium falciparum Precise mechanism not known Bioavailability: ~89% Peak plasma time: 1-2 hr Distributed widely in body tissues (eg, eyes, heart, kidneys, liver, lungs) where retention prolonged; crosses placenta; enters breast milk Partially in liver Half-life: 3-5 days Excretion: urine (~70% as unchanged drug); acidification of urine increases elimination Small amounts may be present in urine months following discontinuation of therapy The above information is provided for general informational and educational purposes only. Contraindications for chloroquine Contraindications for Chloroquine Oral - WebMD, Recommendations for the Prevention of Malaria Among Travelers Does plaquenil come as an injectionChloroquine other drugs in same classLupus like illness normal blood work plaquenil effective Is chloroquine a cure for coronavirus? Some scientists are touting the efficacy of the drug in preliminary studies, but are also noting that much more research needs to be done before confirming. Is Chloroquine a Cure for Coronavirus? Scientists Say.. Chloroquine - Wikipedia. Chloroquine - StatPearls - NCBI Bookshelf. Chloroquine is generally a safe and effective medication. However, as this eMedTV page explains, there are some cases in which it should be avoided. This article lists a few of the contraindications for chloroquine and provides a link to more details. Chloroquine base 15 mg/mL in Glycerin or Distilled Water, Cologel Lilly, and Simple Syrup/Cherry Syrup Pulverize two 500-mg chloroquine phosphate tablets in a mortar. Levigate with a small amount of glycerin or distilled water. Add 13 mL of Cologel, and levigate until a uniform mixture is obtained. Chloroquine can be used for the treatment and prevention of Malaria. Read on for more information on the uses of Chloroquine and its side effects, precautions before this taking this medicine, dosage instructions, and more. Click here for more information on Chloroquine used as Antibiotics.