Solubility of chloroquine in water

Discussion in 'Canada Pharmacy Online' started by AMP1230, 06-Mar-2020.

  1. superxp777aspin Moderator

    Solubility of chloroquine in water


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Nov 21, 2019 Aralen, chloroquine phosphate, USP, is a 4-aminoquinoline compound for oral administration. It is a white, odorless, bitter tasting, crystalline substance, freely soluble in water. Aralen is an antimalarial and amebicidal drug. Feb 20, 2013 Empirically, a series of tests on chloroquine at 20 mg/l in distilled water resulted in a concurrent rise in PO 4 of 4 to 6.1 mg/l, a bit higher than expected*. A rule of thumb might be that for any dose of chloroquine, you could expect to see a rise in phosphate levels of around 20 to 30% of the total dose of chloroquine. An aminoquinoline that is chloroquine in which one of the elementN/element-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against eryt hrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Solubility of chloroquine in water

    Chloroquine C18H26ClN3 ChemSpider, Aquarium Fish Chloroquine A "New" Drug for Treating Fish.

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  7. It is a white, odorless, bitter tasting, crystalline substance, freely soluble in water. Chloroquine Phosphate Tablets are an antimalarial and amebicidal drug. Each tablet, for oral administration, contains 250 mg chloroquine phosphate equivalent to 150 mg base or 500 mg chloroquine phosphate equivalent to 300 mg base.

    • CHLOROQUINE PHOSPHATE TABLETS, USP 250 MG and 500 MG.
    • Hydroxychloroquine C18H26ClN3O ChemSpider.
    • CHLOROQUINE PHOSPHATE, USP.

    The solubilities of chloroquine diphosphate and 4,7-dichloroquinoline in water, ethanol, tetrahydrofuran, acetone, and acetonitrile were measured over the temperature range of 298.2 to 333.2 K. The solubilities of both analytes in different solvents increase smoothly with temperature. The absorption, distribution and elimination of chloroquine were studied in rabbits upon oral administration of chloroquine with aspirin. 2. The time-lag, half-life of absorption and absorption rate constant obtained in both cases were significantly different P 0.01 whereas the half-life of elimination and the elimination rate constant. Solubility guidelines for ionic compounds in water - Guidelines or solubility rules to predict whether or not a given ionic compound is soluble in water at room temperature Solubility product constants - The equilibrium constant, Ksp, for aqueous solutions of ionic compounds at 25°C.

     
  8. metamarket Well-Known Member

    the cause of the most lethal human malaria, chloroquine resistance is linked to multiple mutations in Pf CRT, a protein that likely functions as a transporter in the parasite’s digestive vacuole membrane. Structural and evolutionary analyses of the Plasmodium. Chloroquine - Wikipedia Chloroquine-resistance transporter – NIH Director's Blog
     
  9. saadi Well-Known Member

    Corneal verticillata - American Academy of Ophthalmology Corneal verticillata, or vortex keratopathy, manifests as a whorl-like pattern of golden brown or gray deposits in the inferior interpalpebal portion of the cornea in a clockwise fashion Fig 12-15. A variety of medications bind with the cellular lipids of the basal epithelial layer of the cornea due to their cationic, amphiphilic properties.

    Early Plaquenil Toxicity Detected without Bull’s Eye.