Chloroquine is now uncommonly used in favor of its derivative hydroxychloroquine. In the United States, hydroxychloroquine is most often used for its anti-inflammatory effects in rheumatology and dermatology. Plaquenil for behcet's Chloroquine side effects depression Unfortunately, despite their many benefits, both medications, chloroquine Aralen or its analogue, hydroxychloroquine Plaquenil, carry with them a very small risk of permanent vision loss. Eye screening by an ophthalmologist is important to help identify any damage to the eye at the earliest stage possible. The image of a retinal detachment adjacent to the central area of damaged RPE and photoreceptors is dramatic and unusual, even though this has recently been described. The visual field loss from both glaucoma and hydroxychloroquine toxicity prevented the patient from noticing any subjective visual complaints Figures Figures5 5 and and6. 6. Initially retinal toxicity due to long-term use of chloroquine Aralen for malaria was reported in 1959 by Hobbs et al. 106 Currently, hydroxychloroquine sulphate Plaquenil is the quinoline agent of choice for the treatment of autoimmune diseases with a far lower incidence of adverse reactions. 107, 108 Hydroxychloroquine has been associated with many ocular toxic effects including keratopathy, ciliary body dysfunction, lens opacities, outer retinal damage, and pigmentary retinopathy. While early toxicity may be asymtomatic, patients with more advanced stage of toxicity may complain of color vision changes or paracentral scotomas. Its toxic effects on the retina are seen in the macula. Plaquenil retinal detachment PDF Retinal Detachment in a Patient with Hydroxychloroquine., Retinal Detachment in a Patient with Hydroxychloroquine. Plaquenil cause fungal infectionPlaquenil cost at rite aid Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage. While today it is used to treat autoimmune conditions, such as rheumatoid arthritis and lupus, it was originally used as an anti-malaria drug. Plaquenil Side Effects on Your Eyes and Vision. Ocular side effects of anti-rheumatic medications what a.. Retinal detachment - Symptoms and causes - Mayo Clinic. Lyons emphasizes the importance of annual screening and says that, although annual screening is recommended for everyone taking Plaquenil, it is imperative for people who have been taking the medication for more than 10 years, who have a higher incidence of retinal toxicity. Plaquenil-induced toxicity usually will not occur before five years of. The tri-color macular image showed an inferior hemicircle of pigmentary mottling classic for hydroxychloroquine toxicity, but no obvious retinal detachment Figures Figures1 1 to to4. 4. Clinical exam revealed a shallow inferior retinal detachment. Retinal detachment is a serious vision problem that requires emergency attention. If not addressed immediately, it can lead to permanent vision loss. The condition occurs when part of the retina, the light-sensitive layer of tissue that lines the rear inner surface of the eye, detaches from the choroid layer.