While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners. "Hydrochloroquine (Plaquenil) has been a blessing for me. Chloroquine derived from Hydroxychloroquine plaquenil humira Plaquenil and diahreah Hydroxychloroquine sulphate tablets uses Hi, for anyone that's been on plaquenil long term i've been on more than 2 1/2 years, have you had any moderate to bad flares or flares that dont' seem to go away while taking this med? Or has anyone found that plaquenil stopped working after some time? I've been in some sort of flare for 6 weeks Also known as Plaquenil, Quineprox. The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care. What next if plaquenil doesn't work? Support Forums. Yea, I am allergic to sulfa or I'd be on celebrex right now. I wish the plaquenil was working but it's not. I feel so bad every day. Prednisone ran my blood sugar up but I felt great on it, not that you want to take it for too long. I do occasionally experience dry eyes and a little scalp itch but asserting that it's caused by Hydrochloroquine would be anecdotal at best. It took about 5 weeks to take effect but my RA is basically a non factor now. Plaquenil not working Plaquenil and corona lupus, Hydroxychloroquine User Reviews for Rheumatoid Arthritis at. Aralen canadaHow long do you need to use plaquenilChloroquine primaquine combinationCan plaquenil be taken with naprosyn Plaquenil is NOT known to start working that fast. It takes anywhere from 4-6 months before the affects of Plaquenil are seen/felt. This is the case with everyone I know that takes it. Immune & Autoimmune - Lupus Plaquenil - Can It Work Quickly?. What next if plaquenil doesn't work?. Plaquenil Oral Uses, Side Effects, Interactions.. A rare side effect of Plaquenil is damage to the eye's retina. The retina is the light-sensitive tissue at the back of the eye. Using Plaquenil for a long period of time may harm the retina, causing serious vision loss. People with retinal damage from Plaquenil are not aware at first that they are losing vision. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Plaquenil hydroxychloroquine belongs to a group of medicines called quinolines. Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria.