Had symtoms of malar rash, joint pain especially in hands, fatigue , dry eyes and dry skin . Had a biopsy of skin and confirmed cutaneous lupus. I was put on Plaquenil and for the past 8 years I have been fine with it . Now this year I have been having things pop up that are related to a low immune system. Alternativesto taking plaquenil Baseline reading for plaquenil therapy 2018 Chloroquine and early pregnancy My LLMD just precribed Plaquenil to me. so far so good tho I am concerned about the Vision issues with this medication but from everything I read its very rare to have Vision problems and nothing I read said that it was an Immune suppressant. As with other drugs that may suppress your immune system, talk to your doctor about any vaccines or surgeries you may have. In addition, be sure to notify him/her of any other medications, both prescription and over-the-counter, that you may be taking. Hydroxychloroquine Plaquenil is an antimalarial drug that also has anti-inflammatory qualities and is used to treat certain autoimmune diseases, including rheumatoid arthritis and Sjögren’s disease. Hydroxychloroquine is take orally by mouth. Common side effects include vomiting, headache, changes in vision, and muscle weakness. Does anybody have any input concerning taking Plaquenil for long term therapy ? Some of my doctors think It is the Plaquenil causing it but then some say that Plaquenil is not an immunosuppressant drug that for some reason my immune system is out of wack . I tried to only take 100 mg to see if it would make a difference but I started with terrible joint pain and fatigue so I am back on the 200 mg a day. Hydroxychloroquine immune suppressant Do either hydroxychol/Plaquenil put you at risk for., Treating Lupus with Immunosuppressive Medications Johns. Plaquenil treatment lyme diseasePlaquenil patient assistance applicationPlaquenil for hair loss treatmentHydroxychloroquine-o-acetate Doctors give trusted answers on uses, effects, side-effects, and cautions Dr. Machanic on does hydroxychloroquine suppress the immune system been shown to affect the immune system. It tends to weaken it. Does hydroxychloroquine suppress the immune system.. Immunosuppressants The Myositis Association. Is Plaquenil a immunosuppressant drug ? Autoimmune.. Basically, the immune system is a bit out of control. Plaquenil works by suppressing the immune system. Unfortunately you can't tell it to attack just the germs so you suppress all of its function to spare your healthy tissue- in your husband's case, his eyes, mouth, throat. NOTE Plaquinil and hydroxychloroquine are essentially the same drug. Dosage for Plaquenil. The adult dose of Plaquenil to suppress malaria is 400 mg on the same day each week. The pediatric weekly suppressive dosage is 5 mg/kg of body weight. The adult dose of Plaquenil to treat an acute attack of malaria is an initial dose of 800 mg followed by 400 mg in six to eight hours and 400 mg for two more days. Yes Rituximab rituxin is a monoclonal antibody to cd20 an antigen located on lymphocytes. One consequence of using this drug is a drop in lymphocyte numbers bad cells and good cells. This decline lowers the effectiveness of the immune system for a period of time.